15-hydroxyicosatetraenoate dehydrogenase
In enzymology, a 15-hydroxyicosatetraenoate dehydrogenase (EC 1.1.1.232) is an enzyme that catalyzes the chemical reaction
- (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+ 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H+
| 15-hydroxyicosatetraenoate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.232 | ||||||||
| CAS number | 117910-46-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are 15-Hydroxyicosatetraenoic acid (i.e. 15(S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate), NAD+, and NADP+, whereas its 4 products are 15-oxo-5,8,11-cis-13-trans-icosatetraenoate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase. This enzyme is also called 15-hydroxyeicosatetraenoate dehydrogenase. This enzyme participates in arachidonic acid metabolism.
References
- Sok DE, Kang JB, Shin HD (1988). "15-Hydroxyeicosatetraenoic acid dehydrogenase activity in microsomal fraction of mouse liver homogenate". Biochem. Biophys. Res. Commun. 156 (1): 524–9. doi:10.1016/S0006-291X(88)80873-8. PMID 3052453.