15-hydroxyprostaglandin-I dehydrogenase (NADP+)
In enzymology, a 15-hydroxyprostaglandin-I dehydrogenase (NADP+) (EC 1.1.1.231) is an enzyme that catalyzes the chemical reaction
- (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13- dienoate + NADP+ (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
| 15-hydroxyprostaglandin-I dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.231 | ||||||||
| CAS number | 79468-49-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-, dienoate, and NADP+, whereas its 3 products are (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoa te:NADP+ 15-oxidoreductase. Other names in common use include prostacyclin dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase, NADP+-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase, NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, and 15-hydroxyprostaglandin-I dehydrogenase (NADP+).
References
- Korff JM, Jarabak J (1982). "Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney". Methods Enzymol. 86: 152–5. doi:10.1016/0076-6879(82)86185-5. PMID 6182444.