16S rRNA (adenine1408-N1)-methyltransferase

16S rRNA (adenine1408-N1)-methyltransferase (EC 2.1.1.180, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine1408 in 16S rRNA S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
16S rRNA (adenine1408-N1)-methyltransferase
Identifiers
EC number2.1.1.180
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme provides a panaminoglycoside resistance through interference with the binding of aminoglycosides.

References
  1. Beauclerk AA, Cundliffe E (February 1987). "Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides". Journal of Molecular Biology. 193 (4): 661–71. doi:10.1016/0022-2836(87)90349-4. PMID 2441068.
  2. Koscinski L, Feder M, Bujnicki JM (May 2007). "Identification of a missing sequence and functionally important residues of 16S rRNA:m(1)A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics". Cell Cycle. 6 (10): 1268–71. doi:10.4161/cc.6.10.4231. PMID 17495534.
  3. Holmes DJ, Drocourt D, Tiraby G, Cundliffe E (June 1991). "Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius". Gene. 102 (1): 19–26. doi:10.1016/0378-1119(91)90532-g. PMID 1840536.
  4. Wachino J, Shibayama K, Kurokawa H, Kimura K, Yamane K, Suzuki S, Shibata N, Ike Y, Arakawa Y (December 2007). "Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides". Antimicrobial Agents and Chemotherapy. 51 (12): 4401–9. doi:10.1128/aac.00926-07. PMC 2168023. PMID 17875999.
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