2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase (EC 1.1.1.302, 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, MjaRED, MJ0671 (gene)) is an enzyme with systematic name 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+
| 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.302 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH functions equally well as a reductant.
References
- Graupner M, Xu H, White RH (April 2002). "The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin". Journal of Bacteriology. 184 (7): 1952–7. doi:10.1128/JB.184.7.1952-1957.2002. PMC 134922. PMID 11889103.
- Chatwell L, Krojer T, Fidler A, Römisch W, Eisenreich W, Bacher A, Huber R, Fischer M (June 2006). "Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii". Journal of Molecular Biology. 359 (5): 1334–51. doi:10.1016/j.jmb.2006.04.045. PMID 16730025.
External links
- 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone+5'-phosphate+reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
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