3-Methyl-PCPy

3-Methyl-PCPy is an arylcyclohexylamine derivative with an unusual spectrum of pharmacological effects, acting as both a potent NMDA antagonist and also a triple reuptake inhibitor which inhibits reuptake of all three monoamine neurotransmitters serotonin, dopamine and noradrenaline. It also acts as a high affinity sigma receptor ligand, selective for the σ₂ subtype. It produces both stimulant and dissociative effects in animal behavioural studies.[1][2][3]

3-Methyl-PCPy

Clinical data
ATC code	None
Identifiers
IUPAC name 1-[1-(3-methylphenyl)cyclohexyl]pyrrolidine
CAS Number	1622348-63-3
PubChem CID	137332188
Chemical and physical data
Formula	C17H25N
Molar mass	243.394 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=CC=C1)C2(CCCCC2)N3CCCC3
InChI InChI=1S/C17H25N/c1-15-8-7-9-16(14-15)17(10-3-2-4-11-17)18-12-5-6-13-18/h7-9,14H,2-6,10-13H2,1H3 Key:JZVMREFYFTZXGN-UHFFFAOYSA-N

Legal Status

3-Methyl-PCPy is covered by drug analogue laws in various jurisdictions (UK, Germany, Japan, Australia etc) as a generic arylcyclohexylamine derivative, and a structural isomer of phencyclidine.

See also

• BTCP
• Ephenidine

References

1. Wallach J, De Paoli G, Adejare A, Brandt SD (2014). "Preparation and analytical characterization of 1-(1-phenylcyclohexyl)piperidine (PCP) and 1-(1-phenylcyclohexyl)pyrrolidine (PCPy) analogues". Drug Testing and Analysis. 6 (7–8): 633–50. doi:10.1002/dta.1468. PMID 23554350.
2. Morris H, Wallach J (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis. 6 (7–8): 614–32. doi:10.1002/dta.1620. PMID 24678061.
3. Wallach J, Brandt SD (2018). "Phencyclidine-Based New Psychoactive Substances". Handbook of Experimental Pharmacology. 252: 261–303. doi:10.1007/164_2018_124. PMID 30105474.