AK3

Adenylate kinase 3 is a protein that in humans is encoded by the AK3 gene. [5]

AK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZD8
Identifiers
Aliases	AK3, AK3L1, AK6, AKL3L, AKL3L1, FIX, adenylate kinase 3
External IDs	OMIM: 609290 MGI: 1860835 HomoloGene: 21744 GeneCards: AK3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.1 Start 4,709,556 bp[1] End 4,742,043 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 29,020,833 bp[2] End 29,047,961 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • nucleobase-containing compound kinase activity • GTP binding • ATP binding • GO:0001948 protein binding • phosphotransferase activity, phosphate group as acceptor • kinase activity • nucleoside triphosphate adenylate kinase activity • adenylate kinase activity Cellular component • mitochondrial matrix • mitochondrion Biological process • UTP metabolic process • blood coagulation • nucleobase-containing compound metabolic process • phosphorylation • AMP metabolic process • GTP metabolic process • ITP metabolic process • nucleoside monophosphate phosphorylation • ADP biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50808	56248
Ensembl	ENSG00000147853	ENSMUSG00000024782
UniProt	Q9UIJ7	Q9WTP7
RefSeq (mRNA)	NM_016282 NM_001199852 NM_001199853 NM_001199854 NM_001199855 NM_001199856	NM_021299 NM_001365071
RefSeq (protein)	NP_001186781 NP_001186782 NP_001186784 NP_001186785 NP_057366	NP_067274 NP_001352000
Location (UCSC)	Chr 9: 4.71 – 4.74 Mb	Chr 19: 29.02 – 29.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene.

References

1. GRCh38: Ensembl release 89: ENSG00000147853 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024782 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Adenylate kinase 3". Retrieved 2017-05-19.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human GTP:AMP phosphotransferase AK3, mitochondrial (AK3)

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.