APOL6

Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene.[5][6][7]

APOL6
Identifiers
Aliases	APOL6, APOL-VI, APOLVI, apolipoprotein L6
External IDs	OMIM: 607256 MGI: 1919189 HomoloGene: 49940 GeneCards: APOL6
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 35,648,446 bp[1] End 35,668,404 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 77,044,729 bp[2] End 77,057,106 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • lipid binding Cellular component • extracellular region • cytoplasm Biological process • lipoprotein metabolic process • lipid transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80830	71939
Ensembl	ENSG00000221963	ENSMUSG00000033576
UniProt	Q9BWW8	n/a
RefSeq (mRNA)	NM_030641	NM_001163621 NM_028010
RefSeq (protein)	NP_085144	n/a
Location (UCSC)	Chr 22: 35.65 – 35.67 Mb	Chr 15: 77.04 – 77.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000221963 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033576 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
6. Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells". Mol Cancer Res. 3 (1): 21–31. PMID 15671246.
7. "Entrez Gene: APOL6 apolipoprotein L, 6".

External links

• Human APOL6 genome location and APOL6 gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dominguez O, Ashhab Y, Sabater L, et al. (1999). "Cloning of ARE-containing genes by AU-motif-directed display". Genomics. 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID 9828130.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.