ARFIP1

Arfaptin-1 is a protein that in humans is encoded by the ARFIP1 gene.[4][5][6]

ARFIP1
Identifiers
Aliases	ARFIP1, HSU52521, ADP ribosylation factor interacting protein 1
External IDs	OMIM: 605928 MGI: 1277120 HomoloGene: 8692 GeneCards: ARFIP1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 152,779,937 bp[1] End 152,918,463 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein domain specific binding • phosphatidylinositol-4-phosphate binding • phospholipid binding Cellular component • cytosol • trans-Golgi network membrane • Golgi membrane • cytoplasm Biological process • intracellular protein transport • regulation of Arp2/3 complex-mediated actin nucleation • regulation of protein secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27236	99889
Ensembl	ENSG00000164144	ENSMUSG00000074513
UniProt	P53367	n/a
RefSeq (mRNA)	NM_001025593 NM_001025595 NM_001287431 NM_001287432 NM_001287433 NM_014447	NM_001081093 NM_001293801
RefSeq (protein)	NP_001020764 NP_001020766 NP_001274360 NP_001274361 NP_001274362 NP_055262	n/a
Location (UCSC)	Chr 4: 152.78 – 152.92 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ARFIP1 has been shown to interact with ARF3.[4][5]

References

1. GRCh38: Ensembl release 89: ENSG00000164144 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kanoh H, Williger BT, Exton JH (Apr 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J Biol Chem. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
5. Williger BT, Provost JJ, Ho WT, Milstine J, Exton JH (Aug 1999). "Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D". FEBS Lett. 454 (1–2): 85–9. doi:10.1016/S0014-5793(99)00771-1. PMID 10413101. S2CID 40655171.
6. "Entrez Gene: ARFIP1 ADP-ribosylation factor interacting protein 1 (arfaptin 1)".

Further reading

• Tsai SC, Adamik R, Hong JX, et al. (1998). "Effects of arfaptin 1 on guanine nucleotide-dependent activation of phospholipase D and cholera toxin by ADP-ribosylation factor". J. Biol. Chem. 273 (33): 20697–701. doi:10.1074/jbc.273.33.20697. PMID 9694811.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ho WT, Exton JH, Williger BT (2003). "Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells". FEBS Lett. 537 (1–3): 91–5. doi:10.1016/S0014-5793(03)00098-X. PMID 12606037. S2CID 44551128.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.

External links

• Human ARFIP1 genome location and ARFIP1 gene details page in the UCSC Genome Browser.