ARL4A

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.[5]

ARL4A
Identifiers
Aliases	ARL4A, ARL4, ADP ribosylation factor like GTPase 4A
External IDs	OMIM: 604786 MGI: 99437 HomoloGene: 4194 GeneCards: ARL4A
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.3 Start 12,686,856 bp[1] End 12,690,958 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 B1|12 18.06 cM Start 40,005,447 bp[2] End 40,038,025 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding Cellular component • cell membrane • nucleolus • intracellular • membrane • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • brown fat cell differentiation • intracellular protein transport • vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10124	11861
Ensembl	ENSG00000122644	ENSMUSG00000047446
UniProt	P40617	P61213
RefSeq (mRNA)	NM_212460 NM_001037164 NM_001195396 NM_005738	NM_001039515 NM_007487
RefSeq (protein)	NP_001032241 NP_001182325 NP_005729 NP_997625	NP_001034604 NP_031513
Location (UCSC)	Chr 7: 12.69 – 12.69 Mb	Chr 12: 40.01 – 40.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.[5]

Interactions

ARL4A has been shown to interact with Karyopherin alpha 2.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000122644 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047446 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A".
6. Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal". FEBS Lett. 456 (3): 384–8. doi:10.1016/S0014-5793(99)00759-0. PMID 10462049. S2CID 84422541.
• Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (2001). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.
• Hofmann I, Thompson A, Sanderson CM, Munro S (2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane". Curr. Biol. 17 (8): 711–6. doi:10.1016/j.cub.2007.03.007. PMID 17398095. S2CID 1341183.

External links

• ARL4A human gene location in the UCSC Genome Browser.
• ARL4A human gene details in the UCSC Genome Browser.