Actin nucleation core

An actin nucleation core is a protein trimer with three actin monomers. It is called a nucleation core because it leads to the energetically favorable elongation reaction once a tetramer is formed from a trimer. Actin protein dimers and trimers are energetically unfavorable.[1]

References
  1. Liu, S. L; May, J. R; Helgeson, L. A; Nolen, B. J (2013). "Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex". The Journal of Biological Chemistry. 288 (1): 487–97. doi:10.1074/jbc.M112.406744. PMC 3537046. PMID 23148219.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.