Alcohol dehydrogenase, iron containing 1

Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene.[5]

ADHFE1
Identifiers
Aliases	ADHFE1, ADH8, HOT, HMFT2263, alcohol dehydrogenase, iron containing 1, alcohol dehydrogenase iron containing 1
External IDs	OMIM: 611083 MGI: 1923437 HomoloGene: 5865 GeneCards: ADHFE1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.1 Start 66,432,492 bp[1] End 66,468,907 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A2 Start 9,547,948 bp[2] End 9,580,673 bp[2]
Gene ontology Molecular function • oxidoreductase activity • metal ion binding • hydroxyacid-oxoacid transhydrogenase activity • alcohol dehydrogenase (NAD) activity Cellular component • mitochondrial matrix • mitochondrion • cytosol Biological process • oxidation-reduction process • 2-oxoglutarate metabolic process • glutamate catabolic process via 2-oxoglutarate Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	137872	76187
Ensembl	ENSG00000147576	ENSMUSG00000025911
UniProt	Q8IWW8	Q8R0N6
RefSeq (mRNA)	NM_144650	NM_175236 NM_001357376 NM_001357377 NM_001357378
RefSeq (protein)	NP_653251	NP_780445 NP_001344305 NP_001344306 NP_001344307
Location (UCSC)	Chr 8: 66.43 – 66.47 Mb	Chr 1: 9.55 – 9.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000147576 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025911 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Alcohol dehydrogenase, iron containing 1". Retrieved 2017-06-16.
6. Kardon T, Noël G, Vertommen D, Schaftingen EV (April 2006). "Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate". FEBS Letters. 580 (9): 2347–50. doi:10.1016/j.febslet.2006.02.082. PMID 16616524. S2CID 46525441.

Further reading

• Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y, Mao Y (October 2002). "Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1)". DNA Sequence. 13 (5): 301–6. doi:10.1080/1042517021000011636. PMID 12592711. S2CID 24529446.
• Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM (March 2009). "Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1". Chemico-Biological Interactions. 178 (1–3): 283–7. doi:10.1016/j.cbi.2008.10.025. PMID 19013439.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
• Tae CH, Ryu KJ, Kim SH, Kim HC, Chun HK, Min BH, Chang DK, Rhee PL, Kim JJ, Rhee JC, Kim YH (March 2013). "Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation". BMC Cancer. 13: 142. doi:10.1186/1471-2407-13-142. PMC 3618294. PMID 23517143.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.