All-trans-octaprenyl-diphosphate synthase

All-trans-octaprenyl-diphosphate synthase (EC 2.5.1.90, octaprenyl-diphosphate synthase, octaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-heptaprenyltranstransferase, trans-prenyltransferase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units).[1][2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate 5 diphosphate + all-trans-octaprenyl diphosphate
All-trans-octaprenyl-diphosphate synthase
Identifiers
EC number2.5.1.90
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate.

References
  1. Fujisaki S, Nishino T, Katsuki H (May 1986). "Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis". Journal of Biochemistry. 99 (5): 1327–37. PMID 3519603.
  2. Asai K, Fujisaki S, Nishimura Y, Nishino T, Okada K, Nakagawa T, Kawamukai M, Matsuda H (July 1994). "The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase". Biochemical and Biophysical Research Communications. 202 (1): 340–5. doi:10.1006/bbrc.1994.1933. PMID 8037730.
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