Antonello Bonci

Antonello Bonci is an Italian-American neurologist and a neuropsychopharmacologist specialized in the long-term effects of drug exposure on the brain. In August 2019, he became president of Global Institutes on Addictions Miami. Bonci was previously the scientific director of the National Institute on Drug Abuse and a professor at the University of California, San Francisco.

Antonello Bonci
Alma materUniversità Cattolica del Sacro Cuore (MD)
Scientific career
FieldsNeuropsychopharmacology
InstitutionsUniversity of California, San Francisco
National Institute on Drug Abuse

Education

In 1985, Bonci went to Medical School at the Università Cattolica del Sacro Cuore, where he graduated cum laude in 1991. In that same year, he started a Residency in Neurology at the University of Rome Tor Vergata where he graduated cum laude in 1995.[1]

Career

Bonci became assistant professor in Residence at the University of California, San Francisco in 1999. He became Associate Professor in Residence in 2004, and Professor in Residence in 2007. When he left in 2010, Bonci was Professor in Residence in the Department of Neurology at the University of California, San Francisco (UCSF), the Howard J. Weinberg Endowed Chair in Addiction Research, and the Associate Director for Extramural Affairs at the Ernest Gallo Clinic and Research Center. In 2010, he was appointed as the Scientific Director of National Institute on Drug Abuse's (NIDA).[2] Bonci resigned from his position in August 2019 and accepted a job as President of the Global Institutes on Addictions in Miami. Science (journal) broke the story that Bonci had resigned following a sexual misconduct probe, even though this probe was not mentioned when he first departed.[3][4]

Research

Bonci is known for his studies on the long-term effects of drug exposure on the brain.[5][6] Bonci's laboratory, in collaboration with Robert Malenka, was the first to demonstrate that drugs of abuse, such as cocaine, modify the strength of the connections between neurons.[7] This finding cast a new light on the phenomenon of drug addiction, as a process where maladaptive learning plays a role.[8] Subsequent studies have combined electrophysiological, optogenetic, molecular, and behavioral techniques to determine the long-term effects that are produced by chronic exposure to stress, cocaine or ethanol, with the goal of creating novel therapeutic avenues to decrease the devastating effects of these conditions.[9][10] In 2013, a study lead by Billy T. Chen,[11] provided rationale for the use of non-invasive brain stimulation, such as repeated Transcranial Magnetic Stimulation, in patients with cocaine use disorders. Clinical studies have indeed shown the potential of such technology in the treatment of cocaine use disorders.[12][13][14][15]

Awards and honors

October, 2004 - Jacob P. Waletzky Memorial Award [16]

December, 2009 - Daniel H. Efron Award at the American College of Neuropsychopharmacology [17]

February 6, 2014 - Officer of the Order of the Star of Italy.

November, 2015 - PrimiDieci USA [18]

July, 2016 - Federation of European Neuroscience Societies and European Journal of Neuroscience Award.

October, 2016 - Member of the National Academy of Medicine [19]

References
  1. "Antonello Bonci, M.D. Scientific Director - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse". 2014-02-01. Archived from the original on 2014-02-01. Retrieved 2020-09-10.
  2. "Leading Addiction Researcher Antonello Bonci joins NIDA to lead Intramural Research Program". 26 August 2015. This article incorporates text from this source, which is in the public domain.
  3. WadmanNov. 5, Meredith (5 November 2019). "Science chief at NIH drug abuse institute resigned after sexual misconduct probe". Science | AAAS.
  4. "NIH Official Resigned After Sexual Misconduct Probe". The Scientist Magazine®.
  5. "Laser Light Zaps Away Cocaine Addiction".
  6. "Zap a cocaine addiction with lasers?".
  7. Ungless, Mark A.; Whistler, Jennifer L.; Malenka, Robert C.; Bonci, Antonello (2001). "Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons". Nature. 411 (6837): 583–7. Bibcode:2001Natur.411..583U. doi:10.1038/35079077. PMID 11385572. S2CID 4311436.
  8. Bowers, M. Scott; Chen, Billy T.; Bonci, Antonello (2010). "AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future". Neuron. 67 (1): 11–24. doi:10.1016/j.neuron.2010.06.004. PMC 2904302. PMID 20624588.
  9. Hopf, F. W.; Seif, T.; Bonci, A. (2011). "The SK channel as a novel target for treating alcohol use disorders". Channels (Austin, Tex.). 5 (4): 289–92. doi:10.4161/chan.5.4.16577. PMID 21712648.
  10. Pignatelli, M.; Tejeda, H. A.; Barker, D. J.; Bontempi, L.; Wu, J.; Lopez, A.; Palma Ribeiro, S.; Lucantonio, F.; Parise, E. M.; Torres-Berrio, A.; Alvarez-Bagnarol, Y.; Marino RAM; Cai, Z. L.; Xue, M.; Morales, M.; Tamminga, C. A.; Nestler, E. J.; Bonci, A. (2020). "Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice". Molecular Psychiatry. doi:10.1038/s41380-020-0686-8. PMC 7735389. PMID 32161361.
  11. Chen, B. T.; Yau, H. J.; Hatch, C.; Kusumoto-Yoshida, I.; Cho, S. L.; Hopf, F. W.; Bonci, A. (2013). "Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking". Nature. 496 (7445): 359–62. Bibcode:2013Natur.496..359C. doi:10.1038/nature12024. PMID 23552889. S2CID 4397137.
  12. Terraneo, A.; Leggio, L.; Saladini, M.; Ermani, M.; Bonci, A.; Gallimberti, L. (2016). "Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study". European Neuropsychopharmacology. 26 (1): 37–44. doi:10.1016/j.euroneuro.2015.11.011. PMID 26655188.
  13. Madeo, G.; Terraneo, A.; Cardullo, S.; Gómez Pérez, L. J.; Cellini, N.; Sarlo, M.; Bonci, A.; Gallimberti, L. (2020). "Long-Term Outcome of Repetitive Transcranial Magnetic Stimulation in a Large Cohort of Patients with Cocaine-Use Disorder: An Observational Study". Frontiers in Psychiatry. 11: 158. doi:10.3389/fpsyt.2020.00158. PMC 7059304. PMID 32180745.
  14. Pettorruso, M.; Spagnolo, P. A.; Leggio, L.; Janiri, L.; Di Giannantonio, M.; Gallimberti, L.; Bonci, A.; Martinotti, G. (2018). "Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex may improve symptoms of anhedonia in individuals with cocaine use disorder: A pilot study". Brain Stimulation. 11 (5): 1195–1197. doi:10.1016/j.brs.2018.06.001. PMID 29885861. S2CID 47010124.
  15. Ekhtiari, H.; Tavakoli, H.; Addolorato, G.; Baeken, C.; Bonci, A.; Campanella, S.; Castelo-Branco, L.; Challet-Bouju, G.; Clark, V. P.; Claus, E.; Dannon, P. N.; Del Felice, A.; Den Uyl, T.; Diana, M.; Di Giannantonio, M.; Fedota, J. R.; Fitzgerald, P.; Gallimberti, L.; Grall-Bronnec, M.; Herremans, S. C.; Herrmann, M. J.; Jamil, A.; Khedr, E.; Kouimtsidis, C.; Kozak, K.; Krupitsky, E.; Lamm, C.; Lechner, W. V.; Madeo, G.; et al. (2019). "Transcranial electrical and magnetic stimulation (TES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead". Neuroscience and Biobehavioral Reviews. 104: 118–140. doi:10.1016/j.neubiorev.2019.06.007. hdl:1765/118113. PMC 7293143. PMID 31271802.
  16. "Bulletin Board". May 2005.
  17. http://www.acnp.org/programs/Detail.aspx?cid=6c029175-fd64-4078-83bb-c4161b8ab8a6%5B%5D%5B%5D
  18. "PrimiDieci Society I Global Leaders Network I Ten Best".
  19. "National Academy of Medicine Elects 80 New Members". 17 October 2016.
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