BICD1

Bicaudal D cargo adaptor 1 is a protein that in humans is encoded by the BICD1 gene.[5][6]

BICD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YTD
Identifiers
Aliases	BICD1, BICD, BICD cargo adaptor 1, bic-D 1
External IDs	OMIM: 602204 MGI: 1101760 HomoloGene: 37518 GeneCards: BICD1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.21 Start 32,106,835 bp[1] End 32,383,633 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G3 Start 149,408,886 bp[2] End 149,563,329 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • dynactin binding • Rab GTPase binding • structural constituent of cytoskeleton • proteinase activated receptor binding • GO:0001948 protein binding • cytoskeletal adaptor activity • dynein complex binding • protein kinase binding • dynein intermediate chain binding Cellular component • Golgi apparatus • membrane • host cell viral assembly compartment • trans-Golgi network • tubulin complex • perinuclear region of cytoplasm • cytoplasmic microtubule • cytoskeleton • cytoplasmic vesicle • cytosol • centrosome Biological process • protein localization to organelle • regulation of proteinase activated receptor activity • positive regulation of receptor-mediated endocytosis • RNA processing • microtubule anchoring at microtubule organizing center • negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway • negative regulation of phospholipase C activity • anatomical structure morphogenesis • intracellular mRNA localization • minus-end-directed organelle transport along microtubule • GO:0022415 viral process • stress granule assembly • transport • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to centrosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	636	12121
Ensembl	ENSG00000151746	ENSMUSG00000003452
UniProt	Q96G01	Q8BR07
RefSeq (mRNA)	NM_001003398 NM_001714 NM_001354186 NM_001354187 NM_001354188 NM_001354189 NM_001363603	NM_001112796 NM_009753
RefSeq (protein)	NP_001003398 NP_001705 NP_001341115 NP_001341116 NP_001341117 NP_001341118 NP_001350532	NP_001106267 NP_033883
Location (UCSC)	Chr 12: 32.11 – 32.38 Mb	Chr 6: 149.41 – 149.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[6]

Interactions

BICD1 has been shown to interact with RAB6A.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000151746 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003452 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics. 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.
6. "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".
7. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. S2CID 14031165.
8. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (Dec 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.

External links

• Human BICD1 genome location and BICD1 gene details page in the UCSC Genome Browser.

Further reading

• Barr FA, Short B (Aug 2003). "Golgins in the structure and dynamics of the Golgi apparatus". Current Opinion in Cell Biology. 15 (4): 405–13. doi:10.1016/S0955-0674(03)00054-1. PMID 12892780. Check date values in: |year= / |date= mismatch (help)
• Claussen M, Suter B (Nov 2005). "BicD-dependent localization processes: from Drosophilia development to human cell biology". Annals of Anatomy - Anatomischer Anzeiger. 187 (5–6): 539–53. doi:10.1016/j.aanat.2005.07.004. PMID 16320833. Check date values in: |year= / |date= mismatch (help)
• Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P (Sep 1995). "Isolation and regional assignment of human chromosome 12p cDNAs". Genomics. 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100. Check date values in: |year= / |date= mismatch (help)
• Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. S2CID 14031165. Check date values in: |year= / |date= mismatch (help)
• Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (Dec 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140. Check date values in: |year= / |date= mismatch (help)
• Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Fuchs E, Short B, Barr FA (2006). "Assay and properties of rab6 interaction with dynein-dynactin complexes". Methods in Enzymology. 403: 607–18. doi:10.1016/S0076-6879(05)03053-3. ISBN 9780121828080. PMID 16473624.
• Moorhead AR, Rzomp KA, Scidmore MA (Feb 2007). "The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner". Infection and Immunity. 75 (2): 781–91. doi:10.1128/IAI.01447-06. PMC 1828475. PMID 17101644.
• Fumoto K, Hoogenraad CC, Kikuchi A (Dec 2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". The EMBO Journal. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249. Check date values in: |year= / |date= mismatch (help)
• Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (Oct 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.