BNR/Asp-box repeat

BNR/Asp-box repeat is a repetitive sequence of amino acids contained in some proteins.

BNR/Asp-box repeat
Structure of a bacterial sialidase.[1]
Identifiers
Symbol	BNR
Pfam	PF02012
Pfam clan	CL0434
InterPro	IPR002860
SCOP2	1euu / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes. The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases.[2]

Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes.

Examples

Human genes encoding proteins containing this domain include:

• NEU1
• NEU2
• NEU3
• RELN
• SORCS1
• SORCS2
• SORCS3
• SORL1
• SORT1

References

1. Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure. 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.
2. Copley RR, Russell RB, Ponting CP (February 2001). "Sialidase-like Asp-boxes: sequence-similar structures within different protein folds". Protein Science. 10 (2): 285–92. doi:10.1110/ps.31901. PMC 2373934. PMID 11266614.

This article incorporates text from the public domain Pfam and InterPro: IPR002860