Bacterial recombination

Bacterial recombination is a type of genetic recombination in bacteria characterized by DNA transfer from one organism called donor to another organism as recipient. This process occurs in three main ways:

  • Transformation, the uptake of exogenous DNA from the surrounding environment.
  • Transduction, the virus-mediated transfer of DNA between bacteria.
  • Conjugation, the transfer of DNA from one bacterium to another via cell-to-cell contact.[1][2][3][4]

The final result of conjugation, transduction, and/or transformation is the production of genetic recombinants, individuals that carry not only the genes they inherited from their parent cells but also the genes introduced to their genomes by conjugation, transduction, and/or transformation.[5][6][7]

Recombination in bacteria is ordinarily catalyzed by a RecA type of recombinase.[8] These recombinases promote repair of DNA damages by homologous recombination.[8]

The ability to undergo natural transformation is present in at least 67 bacterial species.[9] Natural transformation is common among pathogenic bacterial species.[10] In some cases, the DNA repair capability provided by recombination during transformation facilitates survival of the infecting bacterial pathogen.[10] Bacterial transformation is carried out by numerous interacting bacterial gene products.[9]

See also

References
  1. Bajrović K, Jevrić-Čaušević A, Hadžiselimović R, eds. (2005). Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB) Sarajevo. ISBN 9958-9344-1-8.
  2. Alberts B, Johnson A, Lewis J, Raff M, Roberts K (2002). Molecular Biology of the Cell (4th ed.). Garland Science. ISBN 0-8153-4072-9.
  3. King RC, Stransfield WD (1998). Dictionary of genetics. New York, Oxford: Oxford University Press. ISBN 0-19-50944-1-7.
  4. Rieger RM, Green MM (1976). Glossary of genetics and cytogenetics: Classical and molecular. Heidelberg - New York: Springer-Verlag. ISBN 3-540-07668-9.
  5. "Recombination". TheFreeDictionary.
  6. Kimball JW (10 February 2017). "Genetic Recombination in Bacteria". Kimball's Biology Pages.
  7. Hiremath DS. "Bacterial recombination".
  8. Hofstatter PG, Tice AK, Kang S, Brown MW, Lahr DJ (October 2016). "Evolution of bacterial recombinase A (recA) in eukaryotes explained by addition of genomic data of key microbial lineages". Proceedings. Biological Sciences. 283 (1840). doi:10.1098/rspb.2016.1453. PMC 5069510. PMID 27708147.
  9. Johnsborg O, Eldholm V, Håvarstein LS (December 2007). "Natural genetic transformation: prevalence, mechanisms and function". Research in Microbiology. 158 (10): 767–78. doi:10.1016/j.resmic.2007.09.004. PMID 17997281.
  10. Bernstein H, Bernstein C, Michod RE (January 2018). "Sex in microbial pathogens". Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 57: 8–25. doi:10.1016/j.meegid.2017.10.024. PMID 29111273.
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