Bruceanol G

Bruceanol G is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties.[1][2]

Bruceanol G

Names
IUPAC name Methyl (1β,11β,12α,13β,15β)-15-{[(2E)-4-acetoxy-3,4-dimethyl-2-pentenoyl]oxy}-1,11,12-trihydroxy-2,16-dioxo-13,20-epoxypicrasan-21-oate
Identifiers
CAS Number	168301-20-0
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL445045
ChemSpider	4944877
PubChem CID	6440620
InChI InChI=1S/C30H40O13/c1-12-8-16(32)23(35)28(6)15(12)10-17-29-11-40-30(26(38)39-7,24(36)19(34)21(28)29)22(29)20(25(37)41-17)42-18(33)9-13(2)27(4,5)43-14(3)31/h9,12,15,17,19-24,34-36H,8,10-11H2,1-7H3/b13-9+/t12-,15+,17-,19-,20-,21-,22-,23-,24+,28+,29-,30+/m1/s1 Key: LNFLSPAGUXRAML-GLQLFLDVSA-N InChI=1S/C30H40O13/c1-12-8-16(32)23(35)28(6)15(12)10-17-29-11-40-30(26(38)39-7,24(36)19(34)21(28)29)22(29)20(25(37)41-17)42-18(33)9-13(2)27(4,5)43-14(3)31/h9,12,15,17,19-24,34-36H,8,10-11H2,1-7H3/b13-9+/t12-,15+,17-,19-,20-,21-,22-,23-,24+,28+,29-,30+/m1/s1 Key: LNFLSPAGUXRAML-GLQLFLDVSA-N
SMILES C[C@@H]1CC(=O)[C@H]([C@]2([C@H]1C[C@@H]3[C@]45[C@@H]2[C@H]([C@@H]([C@]([C@@H]4[C@H](C(=O)O3)OC(=O)/C=C(\C)/C(C)(C)OC(=O)C)(OC5)C(=O)OC)O)O)C)O
Properties
Chemical formula	C30H40O13
Molar mass	608.637 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

• Bruceanol

References

1. Okano, M; Fukamiya, N; Aratani, T; Juichi, M; Lee, KH (1985). "Antitumor agents, 74. Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972–5. doi:10.1021/np50042a017. PMID 3841557.
2. Imamura, K; Fukamiya, N; Nakamura, M; Okano, M; Tagahara, K; Lee, KH (1995). "Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica". Journal of Natural Products. 58 (12): 1915–9. doi:10.1021/np50126a019. PMID 8691212.