CAMK1G (gene)

Calcium/calmodulin dependent protein kinase IG is a protein that in humans is encoded by the CAMK1G gene. [5]

CAMK1G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JAM
Identifiers
Aliases	CAMK1G, CLICK3, CLICKIII, VWS1, dJ272L16.1, calcium/calmodulin dependent protein kinase IG
External IDs	OMIM: 614994 MGI: 2388073 HomoloGene: 48706 GeneCards: CAMK1G
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.2 Start 209,583,714 bp[1] End 209,613,939 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H6|1 97.74 cM Start 193,346,346 bp[2] End 193,370,298 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • catalytic activity • ATP binding • kinase activity • calmodulin-dependent protein kinase activity • calmodulin binding Cellular component • cytoplasm • calcium- and calmodulin-dependent protein kinase complex • neuron projection • Golgi membrane • cell membrane • Golgi apparatus • membrane • endomembrane system • intracellular Biological process • protein phosphorylation • metabolism • phosphorylation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57172	215303
Ensembl	ENSG00000008118	ENSMUSG00000016179
UniProt	Q96NX5	Q91VB2
RefSeq (mRNA)	NM_020439	NM_144817
RefSeq (protein)	NP_065172	NP_659066
Location (UCSC)	Chr 1: 209.58 – 209.61 Mb	Chr 1: 193.35 – 193.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000008118 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016179 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Calcium/calmodulin dependent protein kinase IG". Retrieved 2018-08-28.

Further reading

• Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S, Bito H (May 2003). "Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)". J. Biol. Chem. 278 (20): 18597–605. doi:10.1074/jbc.M300578200. PMID 12637513.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Pang ZP, Xu W, Cao P, Südhof TC (October 2010). "Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons". J. Biol. Chem. 285 (44): 33930–9. doi:10.1074/jbc.M110.150151. PMC 2962493. PMID 20729199.
• Deng M, Wei L, Zuo X, Tian Y, Xie F, Hu P, Zhu C, Yu F, Meng Y, Wang H, Zhang F, Ma H, Ye R, Cheng H, Du J, Dong W, Zhou S, Wang C, Wang Y, Wang J, Chen X, Sun Z, Zhou N, Jiang Y, Liu X, Li X, Zhang N, Liu N, Guan Y, Han Y, Han Y, Lv X, Fu Y, Yu H, Xi C, Xie D, Zhao Q, Xie P, Wang X, Zhang Z, Shen L, Cui Y, Yin X, Cheng H, Liang B, Zheng X, Lee TM, Chen G, Zhou F, Veldink JH, Robberecht W, Landers JE, Andersen PM, Al-Chalabi A, Shaw C, Liu C, Tang B, Xiao S, Robertson J, Zhang F, van den Berg LH, Sun L, Liu J, Yang S, Ju X, Wang K, Zhang X (June 2013). "Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis". Nat. Genet. 45 (6): 697–700. doi:10.1038/ng.2627. PMID 23624525. S2CID 7924012.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.