CAP2

Adenylyl cyclase-associated protein 2 is an enzyme that in humans is encoded by the CAP2 gene.[5][6][7]

CAP2
Identifiers
Aliases	CAP2, CAP, adenylate cyclase-associated protein, 2 (yeast), cyclase associated actin cytoskeleton regulatory protein 2
External IDs	OMIM: 618385 MGI: 1914502 HomoloGene: 101397 GeneCards: CAP2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 17,393,505 bp[1] End 17,557,790 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 46,501,848 bp[2] End 46,650,281 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • actin binding • adenylate cyclase binding • identical protein binding Cellular component • cell membrane • membrane • cortical actin cytoskeleton • GO:0097483, GO:0097481 postsynaptic density Biological process • establishment or maintenance of cell polarity • cytoskeleton organization • signal transduction • activation of adenylate cyclase activity • actin polymerization or depolymerization • cell morphogenesis • regulation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10486	67252
Ensembl	ENSG00000112186	ENSMUSG00000021373
UniProt	P40123	Q9CYT6
RefSeq (mRNA)	NM_006366 NM_001363533 NM_001363534	NM_026056
RefSeq (protein)	NP_006357 NP_001350462 NP_001350463	NP_080332
Location (UCSC)	Chr 6: 17.39 – 17.56 Mb	Chr 13: 46.5 – 46.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin.[7]

Interactions

CAP2 has been shown to interact with CAP1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000112186 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021373 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu G, Swiston J, Young D (Jun 1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins". Journal of Cell Science. 107 (6): 1671–8. PMID 7962207.
6. Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". Journal of Cellular Biochemistry. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.
7. "Entrez Gene: CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)".

External links

• Human CAP2 genome location and CAP2 gene details page in the UCSC Genome Browser.

Further reading

• Shibata R, Mori T, Du W, Chuma M, Gotoh M, Shimazu M, Ueda M, Hirohashi S, Sakamoto M (Sep 2006). "Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis". Clinical Cancer Research. 12 (18): 5363–8. doi:10.1158/1078-0432.CCR-05-2245. PMID 17000669.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.