CCNDBP1

Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.[5][6]

CCNDBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AY5
Identifiers
Aliases	CCNDBP1, DIP1, GCIP, HHM, cyclin D1 binding protein 1
External IDs	OMIM: 607089 MGI: 109595 HomoloGene: 7826 GeneCards: CCNDBP1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.2 Start 43,185,118 bp[1] End 43,197,177 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 60.37 cM Start 121,008,403 bp[2] End 121,016,904 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell nucleus • cytoplasm • nucleoplasm Biological process • regulation of cell cycle • cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23582	17151
Ensembl	ENSG00000166946	ENSMUSG00000023572
UniProt	O95273	Q3TVC7
RefSeq (mRNA)	NM_012142 NM_037370	NM_010761 NM_001355127
RefSeq (protein)	NP_036274	NP_034891 NP_001342056
Location (UCSC)	Chr 15: 43.19 – 43.2 Mb	Chr 2: 121.01 – 121.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.[6]

Interactions

CCNDBP1 has been shown to interact with GRAP2[7] and Cyclin D1.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000166946 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023572 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Aug 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J Biol Chem. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
6. "Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1".
7. Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J. Biol. Chem. UNITED STATES. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. ISSN 0021-9258. PMID 10801854.

Further reading

• Ma W, Xia X, Stafford LJ, et al. (2006). "Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis". Oncogene. 25 (30): 4207–16. doi:10.1038/sj.onc.1209450. PMID 16501603.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chang MS, Chen CY, Yeh HI, et al. (2003). "Cloning, expression, and genomic organization of mouse mp29 gene". Biochem. Biophys. Res. Commun. 299 (2): 241–6. doi:10.1016/S0006-291X(02)02605-0. PMID 12437976.
• Dgany O, Avidan N, Delaunay J, et al. (2003). "Congenital Dyserythropoietic Anemia Type I Is Caused by Mutations in Codanin-1". Am. J. Hum. Genet. 71 (6): 1467–74. doi:10.1086/344781. PMC 378595. PMID 12434312.
• Terai S, Aoki H, Ashida K, Thorgeirsson SS (2000). "Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression". Hepatology. 32 (2): 357–66. doi:10.1053/jhep.2000.9092. PMID 10915743.
• Yamada S, Iida T, Tabata T, et al. (2000). "Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat". Hepatology. 32 (2): 278–88. doi:10.1053/jhep.2000.9604. PMID 10915734.
• Yao Y, Doki Y, Jiang W, et al. (2000). "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins". Exp. Cell Res. 257 (1): 22–32. doi:10.1006/excr.2000.4884. PMID 10854051.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• Human CCNDBP1 genome location and CCNDBP1 gene details page in the UCSC Genome Browser.