CCNG2

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.[4][5]

CCNG2
Identifiers
Aliases	CCNG2, cyclin G2
External IDs	OMIM: 603203 MGI: 1095734 HomoloGene: 3208 GeneCards: CCNG2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 77,157,207 bp[1] End 77,433,388 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • protein kinase binding Cellular component • cytoplasm • cyclin-dependent protein kinase holoenzyme complex • cell nucleus Biological process • cell cycle • regulation of cell cycle • cell division • regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0007067 mitotic cell cycle • protein phosphorylation • regulation of mitotic nuclear division • positive regulation of cell proliferation • positive regulation of cell cycle • mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	901	12452
Ensembl	ENSG00000138764	ENSMUSG00000029385
UniProt	Q16589	O08918
RefSeq (mRNA)	NM_004354	NM_007635
RefSeq (protein)	NP_004345	NP_031661
Location (UCSC)	Chr 4: 77.16 – 77.43 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.[5]

Interactions

CCNG2 has been shown to interact with PPP2CA.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138764 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.
5. "Entrez Gene: CCNG2 cyclin G2".
6. Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.

External links

• Human CCNG2 genome location and CCNG2 gene details page in the UCSC Genome Browser.

Further reading

• Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF (1996). "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression". J. Biol. Chem. 271 (11): 6050–61. doi:10.1074/jbc.271.11.6050. PMID 8626390.
• Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.
• Tian YL, Liu FR, Liu J, Jiang L, Luo Y, Zhang X (2002). "[Ectopic expression of cyclin G2 inhibits cell proliferation in HeLa cancer cell line]". AI Zheng. 21 (6): 577–81. PMID 12452053.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Bergqvist M, Brattström D, Brodin D, Lindkvist A, Dahlman-Wright K, Dreilich M, Wagenius G, Paulsson-Karlsson Y (2006). "Genes associated with telomerase activity levels in esophageal carcinoma cell lines". Dis. Esophagus. 19 (1): 20–3. doi:10.1111/j.1442-2050.2006.00532.x. PMID 16364039.
• Stossi F, Likhite VS, Katzenellenbogen JA, Katzenellenbogen BS (2006). "Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter". J. Biol. Chem. 281 (24): 16272–8. doi:10.1074/jbc.M513405200. PMID 16608856.
• Arachchige Don AS, Dallapiazza RF, Bennin DA, Brake T, Cowan CE, Horne MC (2006). "Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest". Exp. Cell Res. 312 (20): 4181–204. doi:10.1016/j.yexcr.2006.09.023. PMC 1862360. PMID 17123511.