CD2BP2

CD2 antigen cytoplasmic tail-binding protein 2 is a protein that in humans is encoded by the CD2BP2 gene.[5][6]

CD2BP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GYF, 1L2Z, 1SYX, 4BWS
Identifiers
Aliases	CD2BP2, FWP010, LIN1, PPP1R59, Snu40, U5-52K, CD2 (cytoplasmic tail) binding protein 2, CD2 cytoplasmic tail binding protein 2
External IDs	OMIM: 604470 MGI: 1917483 HomoloGene: 4455 GeneCards: CD2BP2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,350,773 bp[1] End 30,355,308 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,191,660 bp[2] End 127,196,050 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ribonucleoprotein complex binding • GO:0001948 protein binding Cellular component • U5 snRNP • nuclear speck • U4/U6 x U5 tri-snRNP complex • cell nucleus • nucleoplasm • fibrillar center • cytoplasm • cytosol Biological process • negative regulation of phosphatase activity • mRNA splicing, via spliceosome • mRNA processing • spliceosomal tri-snRNP complex assembly • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10421	70233
Ensembl	ENSG00000169217	ENSMUSG00000042502
UniProt	O95400	Q9CWK3
RefSeq (mRNA)	NM_006110 NM_001243646	NM_001285905 NM_001285906 NM_001285907 NM_027353 NM_001357817
RefSeq (protein)	NP_001230575 NP_006101 NP_001230575.1 NP_006101.1	NP_001272834 NP_001272835 NP_001272836 NP_081629 NP_001344746
Location (UCSC)	Chr 16: 30.35 – 30.36 Mb	Chr 7: 127.19 – 127.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CD2BP2 has been shown to interact with CD2.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000169217 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042502 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A. 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
6. "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation". RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
• Cohavy O, Zhou J, Ware CF, Targan SR (2005). "LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling". J. Immunol. 174 (2): 646–53. doi:10.4049/jimmunol.174.2.646. PMID 15634882.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kofler M, Heuer K, Zech T, Freund C (2004). "Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2". J. Biol. Chem. 279 (27): 28292–7. doi:10.1074/jbc.M402008200. PMID 15105431.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Freund C, Kühne R, Yang H, et al. (2003). "Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules". EMBO J. 21 (22): 5985–95. doi:10.1093/emboj/cdf602. PMC 137194. PMID 12426371.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Freund C, Dötsch V, Nishizawa K, et al. (1999). "The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences". Nat. Struct. Biol. 6 (7): 656–60. doi:10.1038/10712. PMID 10404223. S2CID 19688996.

External links

• Human CD2BP2 genome location and CD2BP2 gene details page in the UCSC Genome Browser.