CD3EAP

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene.[5][6][7][8]

POLR1G
Identifiers
Aliases	POLR1G, ASE-1, ASE1, CAST, PAF49, CD3e molecule associated protein, RPA34, RNA polymerase I subunit G, CD3EAP
External IDs	OMIM: 107325 MGI: 1917583 HomoloGene: 17107 GeneCards: POLR1G
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,406,209 bp[1] End 45,410,766 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 19,356,014 bp[2] End 19,359,483 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA-directed 5'-3' RNA polymerase activity • RNA binding Cellular component • DNA-directed RNA polymerase I complex • RNA polymerase I transcription factor complex • mitochondrion • cell nucleus • nucleoplasm • chromosome • fibrillar center • nucleolus • cytosol Biological process • transcription initiation from RNA polymerase I promoter • termination of RNA polymerase I transcription • positive regulation of gene expression, epigenetic • rRNA transcription • transcription elongation from RNA polymerase I promoter • transmembrane receptor protein tyrosine kinase signaling pathway • transcription from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10849	70333
Ensembl	ENSG00000117877	ENSMUSG00000047649
UniProt	O15446	Q76KJ5
RefSeq (mRNA)	NM_012099 NM_001297590	NM_145822
RefSeq (protein)	NP_001284519 NP_036231	NP_665821
Location (UCSC)	Chr 19: 45.41 – 45.41 Mb	Chr 7: 19.36 – 19.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain,[5] POLR1E[7] and POLR1C.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000117877 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047649 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (Jul 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J Biol Chem. 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. PMID 10373416.
6. Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (Mar 1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes". Chromosoma. 106 (8): 493–502. doi:10.1007/s004120050271. PMID 9426281. S2CID 10684078.
7. Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jun 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol Cell Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
8. "Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
• Panov KI, Panova TB, Gadal O, et al. (2006). "RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor". Mol. Cell. Biol. 26 (14): 5436–48. doi:10.1128/MCB.00230-06. PMC 1592716. PMID 16809778.
• Skjelbred CF, Saebø M, Nexø BA, et al. (2006). "Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study". BMC Cancer. 6: 175. doi:10.1186/1471-2407-6-175. PMC 1533843. PMID 16817948.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

External links

• Human CAST genome location and CAST gene details page in the UCSC Genome Browser.
• Human CD3EAP genome location and CD3EAP gene details page in the UCSC Genome Browser.