CDCA7

Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene.[5][6][7]

CDCA7
Identifiers
Aliases	CDCA7, JPO1, ICF3, cell division cycle associated 7
External IDs	OMIM: 609937 MGI: 1914203 HomoloGene: 49970 GeneCards: CDCA7
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 173,354,820 bp[1] End 173,368,997 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 72,476,159 bp[2] End 72,486,893 bp[2]
Orthologs
Species	Human	Mouse
Entrez	83879	66953
Ensembl	ENSG00000144354	ENSMUSG00000055612
UniProt	Q9BWT1	Q9D0M2
RefSeq (mRNA)	NM_031942 NM_145810	NM_025866
RefSeq (protein)	NP_114148 NP_665809	NP_080142
Location (UCSC)	Chr 2: 173.35 – 173.37 Mb	Chr 2: 72.48 – 72.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144354 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055612 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi:10.1074/jbc.M107357200. PMID 11598121.
6. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
7. "Entrez Gene: CDCA7 cell division cycle associated 7".

External links

• Human CDCA7 genome location and CDCA7 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Osthus RC, Karim B, Prescott JE, et al. (2005). "The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo". Cancer Res. 65 (13): 5620–7. doi:10.1158/0008-5472.CAN-05-0536. PMC 1224734. PMID 15994934.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Goto Y, Hayashi R, Muramatsu T, et al. (2006). "JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity". Biochim. Biophys. Acta. 1759 (1–2): 60–8. doi:10.1016/j.bbaexp.2006.02.004. PMID 16580749.