CFHR3

Complement factor H-related protein 3 is a protein that in humans is encoded by the CFHR3 gene.[3][4][5]

CFHR3
Identifiers
Aliases	CFHR3, CFHL3, DOWN16, FHR-3, FHR3, HLF4, complement factor H related 3
External IDs	OMIM: 605336 HomoloGene: 137347 GeneCards: CFHR3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.3 Start 196,774,795 bp[1] End 196,795,406 bp[1]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10878	n/a
Ensembl	ENSG00000116785	n/a
UniProt	Q02985	n/a
RefSeq (mRNA)	NM_001166624 NM_021023	n/a
RefSeq (protein)	NP_001160096 NP_066303	n/a
Location (UCSC)	Chr 1: 196.77 – 196.8 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000116785 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Skerka C, Kuhn S, Gunther K, Lingelbach K, Zipfel PF (Mar 1993). "A novel short consensus repeat-containing molecule is related to human complement factor H". J Biol Chem. 268 (4): 2904–8. doi:10.1016/S0021-9258(18)53859-X. PMID 8428964.
4. Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701. S2CID 31776506.
5. "Entrez Gene: CFHR3 complement factor H-related 3".

Further reading

• Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today. 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
• Hellwage J, Jokiranta TS, Koistinen V, et al. (2000). "Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin". FEBS Lett. 462 (3): 345–52. doi:10.1016/S0014-5793(99)01554-9. PMID 10622723.
• Male DA, Ormsby RJ, Ranganathan S, et al. (2000). "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes". Mol. Immunol. 37 (1–2): 41–52. doi:10.1016/S0161-5890(00)00024-9. PMID 10781834.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Zipfel PF, Edey M, Heinen S, et al. (2007). "Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome". PLOS Genet. 3 (3): e41. doi:10.1371/journal.pgen.0030041. PMC 1828695. PMID 17367211.

External links

• GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
• OMIM entries on Atypical Hemolytic-Uremic Syndrome
• Human CFHR3 genome location and CFHR3 gene details page in the UCSC Genome Browser.