CHD1

Chromodomain-helicase-DNA-binding protein 1 is a chromatin remodeler that in humans is encoded by the CHD1 gene.[5][6][7]

CHD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B2T, 2B2U, 2B2V, 2B2W, 2B2Y, 4B4C, 4NW2, 4O42, 5AFW, 2N39
Identifiers
Aliases	CHD1, chromodomain helicase DNA binding protein 1, PILBOS, CHD-1
External IDs	OMIM: 602118 MGI: 88393 HomoloGene: 68174 GeneCards: CHD1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q15-q21.1 Start 98,853,985 bp[1] End 98,928,957 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A2|17 8.95 cM Start 15,704,967 bp[2] End 15,772,610 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0004003 DNA helicase activity • nucleotide binding • GO:0001948 protein binding • hydrolase activity • ATP binding • GO:0008026 helicase activity • methylated histone binding Cellular component • cytoplasm • cell nucleus • fibrillar center • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • chromatin remodeling • regulation of transcription, DNA-templated • positive regulation by host of viral transcription • transcription, DNA-templated • DNA duplex unwinding • chromatin organization • covalent chromatin modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1105	12648
Ensembl	ENSG00000153922	ENSMUSG00000023852
UniProt	O14646	P40201
RefSeq (mRNA)	NM_001270 NM_001364113 NM_001376194	NM_007690
RefSeq (protein)	NP_001261 NP_001351042 NP_001363123	NP_031716
Location (UCSC)	Chr 5: 98.85 – 98.93 Mb	Chr 17: 15.7 – 15.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD proteins are chromatin remodelers that primarily work through repositioning nucleosomes along the DNA template. .[7]

CHD1 has three domains characteristic of CHD proteins: tandem chromodomains, an ATPase domain, and a DNA-binding domain.

CHD1 proteins are conserved across organisms.

Interactions

CHD1 has been shown to interact with Nuclear receptor co-repressor 1.[8]

Human Health

Alterations in the CHD1 gene have been linked to prostate cancer[9] and hereditary gastric cancer.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000153922 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023852 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Delmas V, Stokes DG, Perry RP (March 1993). "A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2414–8. Bibcode:1993PNAS...90.2414D. doi:10.1073/pnas.90.6.2414. PMC 46097. PMID 8460153.
6. Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS (October 1997). "Characterization of the CHD family of proteins". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11472–7. Bibcode:1997PNAS...9411472W. doi:10.1073/pnas.94.21.11472. PMC 23509. PMID 9326634.
7. "Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1".
8. Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW (August 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochemical and Biophysical Research Communications. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID 12890497.
9. Huang, S.; Gulzar, Z. G.; Salari, K.; Lapointe, J.; Brooks, J. D.; Pollack, J. R. (September 2012). "Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness". Oncogene. 31 (37): 4164–4170. doi:10.1038/onc.2011.590. ISSN 1476-5594.
10. Grady, William M.; Willis, Joseph; Guilford, Parry J.; Dunbier, Anita K.; Toro, Tumi T.; Lynch, Henry; Wiesner, Georgia; Ferguson, Kelly; Eng, Charis; Park, Jae-Gahb; Kim, Seong-Jin (September 2000). "Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer". Nature Genetics. 26 (1): 16–17. doi:10.1038/79120. ISSN 1546-1718.

External links

• Human CHD1 genome location and CHD1 gene details page in the UCSC Genome Browser.

Further reading

• Stokes DG, Perry RP (May 1995). "DNA-binding and chromatin localization properties of CHD1". Molecular and Cellular Biology. 15 (5): 2745–53. doi:10.1128/mcb.15.5.2745. PMC 230505. PMID 7739555.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kelley DE, Stokes DG, Perry RP (April 1999). "CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin". Chromosoma. 108 (1): 10–25. doi:10.1007/s004120050347. PMID 10199952. S2CID 12945778.
• Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, et al. (January 2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
• Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW (August 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochemical and Biophysical Research Communications. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID 12890497.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Sims RJ, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D (December 2005). "Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains". The Journal of Biological Chemistry. 280 (51): 41789–92. doi:10.1074/jbc.C500395200. PMC 1421377. PMID 16263726.
• Flanagan JF, Mi LZ, Chruszcz M, Cymborowski M, Clines KL, Kim Y, et al. (December 2005). "Double chromodomains cooperate to recognize the methylated histone H3 tail". Nature. 438 (7071): 1181–5. Bibcode:2005Natur.438.1181F. doi:10.1038/nature04290. PMID 16372014. S2CID 4401500.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Okuda M, Horikoshi M, Nishimura Y (January 2007). "Structural polymorphism of chromodomains in Chd1". Journal of Molecular Biology. 365 (4): 1047–62. doi:10.1016/j.jmb.2006.10.039. PMID 17098252.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.