CHMP4B

Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.[5][6]

CHMP4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C3Q, 3UM3, 4ABM
Identifiers
Aliases	CHMP4B, C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4, charged multivesicular body protein 4B
External IDs	OMIM: 610897 MGI: 1922858 HomoloGene: 57102 GeneCards: CHMP4B
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 33,811,348 bp[1] End 33,854,366 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 154,651,705 bp[2] End 154,694,785 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • GO:0001948 protein binding • identical protein binding • cadherin binding Cellular component • cytoplasm • ESCRT III complex • cytosol • endosome • membrane • late endosome membrane • cytoplasmic side of plasma membrane • membrane coat • extracellular exosome • vesicle • midbody • nuclear envelope • cell nucleus Biological process • negative regulation of autophagosome assembly • regulation of centrosome duplication • GO:0019067 viral life cycle • nucleus organization • maintenance of lens transparency • multivesicular body assembly • negative regulation of cell death • regulation of mitotic spindle assembly • autophagy • endosomal transport • posttranslational protein targeting to endoplasmic reticulum membrane • ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway • protein transport • cell separation after cytokinesis • mitotic metaphase plate congression • protein homooligomerization • vacuolar transport • negative regulation of neuron death • nuclear envelope reassembly • exit from mitosis • mitotic cytokinesis • regulation of autophagy • membrane fission • macroautophagy • transport • viral budding via host ESCRT complex • midbody abscission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	128866	75608
Ensembl	ENSG00000101421	ENSMUSG00000038467
UniProt	Q9H444	Q9D8B3
RefSeq (mRNA)	NM_176812	NM_029362
RefSeq (protein)	NP_789782	NP_083638
Location (UCSC)	Chr 20: 33.81 – 33.85 Mb	Chr 2: 154.65 – 154.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000101421 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038467 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
6. "Entrez Gene: CHMP4B chromatin modifying protein 4B".

External links

• Human CHMP4A genome location and CHMP4A gene details page in the UCSC Genome Browser.
• Human CHMP4B genome location and CHMP4B gene details page in the UCSC Genome Browser.

Further reading

• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh K, Shibata H, Suzuki H, et al. (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
• Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
• Sharma M, Pampinella F, Nemes C, et al. (2004). "Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes". J. Cell Biol. 164 (6): 923–33. doi:10.1083/jcb.200312018. PMC 2172283. PMID 15007060.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yorikawa C, Shibata H, Waguri S, et al. (2005). "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting". Biochem. J. 387 (Pt 1): 17–26. doi:10.1042/BJ20041227. PMC 1134928. PMID 15511219.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
• Usami Y, Popov S, Göttlinger HG (2007). "Potent Rescue of Human Immunodeficiency Virus Type 1 Late Domain Mutants by ALIX/AIP1 Depends on Its CHMP4 Binding Site". J. Virol. 81 (12): 6614–22. doi:10.1128/JVI.00314-07. PMC 1900090. PMID 17428861.
• Shiels A, Bennett TM, Knopf HL, et al. (2007). "CHMP4B, a Novel Gene for Autosomal Dominant Cataracts Linked to Chromosome 20q". Am. J. Hum. Genet. 81 (3): 596–606. doi:10.1086/519980. PMC 1950844. PMID 17701905.