CHST10

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.[5][6]

CHST10
Identifiers
Aliases	CHST10, HNK-1ST, HNK1ST, carbohydrate sulfotransferase 10
External IDs	OMIM: 606376 MGI: 2138283 HomoloGene: 21013 GeneCards: CHST10
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 100,391,860 bp[1] End 100,417,668 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 38,863,867 bp[2] End 38,898,161 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • sulfotransferase activity • HNK-1 sulfotransferase activity Cellular component • integral component of membrane • Golgi membrane • Golgi apparatus • membrane Biological process • cell adhesion • carbohydrate biosynthetic process • carbohydrate metabolic process • proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9486	98388
Ensembl	ENSG00000115526	ENSMUSG00000026080
UniProt	O43529	Q6PGK7
RefSeq (mRNA)	NM_004854	NM_145142 NM_001368780
RefSeq (protein)	NP_004845	NP_660124 NP_001355709
Location (UCSC)	Chr 2: 100.39 – 100.42 Mb	Chr 1: 38.86 – 38.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000115526 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026080 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.
6. "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

External links

• Human CHST10 genome location and CHST10 gene details page in the UCSC Genome Browser.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ong E, Yeh JC, Ding Y, et al. (1999). "Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis". J. Biol. Chem. 274 (36): 25608–12. doi:10.1074/jbc.274.36.25608. PMID 10464296.
• Ong E, Yeh JC, Ding Y, et al. (1998). "Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids". J. Biol. Chem. 273 (9): 5190–5. doi:10.1074/jbc.273.9.5190. PMID 9478973.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.