CIC (gene)

Protein capicua homolog is a protein that in humans is encoded by the CIC gene.[5][6][7]

CIC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M41, 4J2J, 4J2L
Identifiers
Aliases	CIC, capicua transcriptional repressor, MRD45
External IDs	OMIM: 612082 MGI: 1918972 HomoloGene: 87637 GeneCards: CIC
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 42,268,537 bp[1] End 42,295,797 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 25,267,704 bp[2] End 25,294,159 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm • intracellular membrane-bounded organelle • macromolecular complex Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • brain development • learning • memory • social organism behavior • negative regulation of transcription, DNA-templated • lung alveolus development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23152	71722
Ensembl	ENSG00000079432	ENSMUSG00000005442
UniProt	Q96RK0	Q924A2
RefSeq (mRNA)	NM_001304815 NM_015125 NM_001379480 NM_001379482 NM_001379484 NM_001379485	NM_001110131 NM_001110132 NM_027882 NM_001302811
RefSeq (protein)	NP_001291744 NP_055940 NP_001366409 NP_001366411 NP_001366413 NP_001366414	NP_001289740 NP_082158
Location (UCSC)	Chr 19: 42.27 – 42.3 Mb	Chr 7: 25.27 – 25.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000079432 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005442 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee CJ, Chan WI, Cheung M, Cheng YC, Appleby VJ, Orme AT, Scotting PJ (Oct 2002). "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons". Brain Res Mol Brain Res. 106 (1–2): 151–6. doi:10.1016/S0169-328X(02)00439-4. PMID 12393275.
6. Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas". J Neurooncol. 73 (2): 101–8. doi:10.1007/s11060-004-4598-2. PMID 15981098. S2CID 24938086.
7. "Entrez Gene: CIC capicua transcriptional repressor [ Homo sapiens (human) ]".

External links

• Human CIC genome location and CIC gene details page in the UCSC Genome Browser.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.