CIDEA

Cell death activator CIDE-A is a protein that in humans is encoded by the CIDEA gene.[5][6][7] Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.[8]

CIDEA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EEL
Identifiers
Aliases	CIDEA, CIDE-A, cell death-inducing DFFA-like effector a, cell death inducing DFFA like effector a
External IDs	OMIM: 604440 MGI: 1270845 HomoloGene: 77852 GeneCards: CIDEA
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.21|18 Start 12,254,361 bp[1] End 12,277,595 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 67,343,604 bp[2] End 67,367,785 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity Cellular component • cytoplasm • lipid droplet • intracellular • mitochondrion • mitochondrial envelope • cell nucleus • cytosol Biological process • regulation of apoptotic process • negative regulation of execution phase of apoptosis • regulation of transcription, DNA-templated • lipid metabolism • lipid storage • cell death • negative regulation of transforming growth factor beta receptor signaling pathway • transcription, DNA-templated • positive regulation of sequestering of triglyceride • negative regulation of cytokine secretion • response to stilbenoid • negative regulation of tumor necrosis factor production • temperature homeostasis • negative regulation of lipid catabolic process • regulation of apoptotic DNA fragmentation • apoptotic process • lipid particle organization • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1149	12683
Ensembl	ENSG00000176194	ENSMUSG00000024526
UniProt	O60543	O70302
RefSeq (mRNA)	NM_001279 NM_001318383	NM_007702
RefSeq (protein)	NP_001270 NP_001305312	NP_031728
Location (UCSC)	Chr 18: 12.25 – 12.28 Mb	Chr 18: 67.34 – 67.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000176194 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024526 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inohara N, Koseki T, Chen S, Wu X, Nunez G (Jun 1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor" (PDF). EMBO J. 17 (9): 2526–33. doi:10.1093/emboj/17.9.2526. PMC 1170594. PMID 9564035.
6. Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP (Jun 2008). "Cidea is associated with lipid droplets and insulin sensitivity in humans". Proc Natl Acad Sci U S A. 105 (22): 7833–8. doi:10.1073/pnas.0802063105. PMC 2409392. PMID 18509062.
7. "Entrez Gene: CIDEA cell death-inducing DFFA-like effector a".
8. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids

External links

• Human CIDEA genome location and CIDEA gene details page in the UCSC Genome Browser.

Further reading

• Zhang L, Miyaki K, Nakayama T, Muramatsu M (2008). "Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men". Metab. Clin. Exp. 57 (4): 502–5. doi:10.1016/j.metabol.2007.11.011. PMID 18328351.
• Li D, Da L, Tang H, et al. (2008). "CpG methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing DFF45-like effector A gene through the regulation of Sp1/Sp3 binding". Nucleic Acids Res. 36 (1): 330–41. doi:10.1093/nar/gkm1028. PMC 2248752. PMID 18033804.
• Gummesson A, Jernås M, Svensson PA, et al. (2008). "Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studies". J. Clin. Endocrinol. Metab. 92 (12): 4759–65. doi:10.1210/jc.2007-1136. PMID 17895319.
• Iwahana H, Yakymovych I, Dubrovska A, et al. (2007). "Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis". Proteomics. 6 (23): 6168–80. doi:10.1002/pmic.200600384. PMID 17080483.
• Dahlman I, Kaaman M, Jiao H, et al. (2005). "The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects". Diabetes. 54 (10): 3032–4. doi:10.2337/diabetes.54.10.3032. PMID 16186410.
• Nordström EA, Rydén M, Backlund EC, et al. (2005). "A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity". Diabetes. 54 (6): 1726–34. doi:10.2337/diabetes.54.6.1726. PMID 15919794.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhou Z, Yon Toh S, Chen Z, et al. (2003). "Cidea-deficient mice have lean phenotype and are resistant to obesity". Nat. Genet. 35 (1): 49–56. doi:10.1038/ng1225. PMID 12910269. S2CID 12428229.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen Z, Guo K, Toh SY, et al. (2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis". J. Biol. Chem. 275 (30): 22619–22. doi:10.1074/jbc.C000207200. PMID 10837461.