CKS2

Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene.[5][6][7]

CKS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CKS, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CKS2, CKSHS2, CDC28 protein kinase regulatory subunit 2
External IDs	OMIM: 116901 MGI: 1913447 HomoloGene: 86883 GeneCards: CKS2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.2 Start 89,311,195 bp[1] End 89,316,703 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 51,645,232 bp[2] End 51,650,660 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cyclin-dependent protein serine/threonine kinase regulator activity • chromatin binding • histone binding • protein kinase binding • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity • ubiquitin binding • GO:0001948 protein binding Cellular component • SCF ubiquitin ligase complex • cyclin-dependent protein kinase holoenzyme complex Biological process • cell cycle • meiosis I • cell division • regulation of mitotic cell cycle • positive regulation of cyclin-dependent protein serine/threonine kinase activity • cellular proliferation • positive regulation of transcription, DNA-templated • mitotic cell cycle phase transition • regulation of transcription from RNA polymerase II promoter • regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1164	66197
Ensembl	ENSG00000123975	ENSMUSG00000062248
UniProt	P33552	P56390
RefSeq (mRNA)	NM_001827	NM_025415
RefSeq (protein)	NP_001818	NP_079691
Location (UCSC)	Chr 9: 89.31 – 89.32 Mb	Chr 13: 51.65 – 51.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000123975 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062248 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI (Dec 1990). "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe". Genes Dev. 4 (8): 1332–44. doi:10.1101/gad.4.8.1332. PMID 2227411.
6. Demetrick DJ, Zhang H, Beach DH (Sep 1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22". Cytogenet Cell Genet. 73 (3): 250–4. doi:10.1159/000134349. PMID 8697818.
7. "Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2".

External links

• Human CKS2 genome location and CKS2 gene details page in the UCSC Genome Browser.

Further reading

• Parge HE, Arvai AS, Murtari DJ, et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science. 262 (5132): 387–95. doi:10.1126/science.8211159. PMID 8211159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
• Gorr IH, Boos D, Stemmann O (2005). "Mutual inhibition of separase and Cdk1 by two-step complex formation". Mol. Cell. 19 (1): 135–41. doi:10.1016/j.molcel.2005.05.022. PMID 15989971.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Rother K, Dengl M, Lorenz J, et al. (2007). "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73". FEBS Lett. 581 (6): 1166–72. doi:10.1016/j.febslet.2007.02.028. PMID 17336302. S2CID 6953397.
• Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731. PMID 17388661.