CM-4620

CM-4620 is a drug which acts as a selective inhibitor of the calcium channel ORAI1. It has antiinflammatory effects and is being researched for the treatment of pancreatitis.[1]

CM-4620

Identifiers
IUPAC name N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro-6-methylbenzamide
CAS Number	1713240-67-5
PubChem CID	122507647
ChemSpider	58810276
Chemical and physical data
Formula	C19H11ClF3N3O3
Molar mass	421.8 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F
InChI InChI=1S/C19H11ClF3N3O3/c1-9-3-2-4-12(21)17(9)18(27)26-16-8-24-13(7-25-16)10-5-14-15(6-11(10)20)29-19(22,23)28-14/h2-8H,1H3,(H,25,26,27) Key:QQMKTHUGOQDEIL-UHFFFAOYSA-N

References

1. Waldron RT, Chen Y, Pham H, Go A, Su HY, Hu C, et al. (June 2019). "The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis". The Journal of Physiology. 597 (12): 3085–3105. doi:10.1113/JP277856. PMC 6582954. PMID 31050811.