CNKSR3

CNKSR family member 3 is a protein that in humans is encoded by the CNKSR3 gene. [5]

CNKSR3
Identifiers
Aliases	CNKSR3, MAGI1, CNKSR family member 3, CNK3, CNK3/IPCEF1
External IDs	OMIM: 617476 MGI: 2674130 HomoloGene: 18192 GeneCards: CNKSR3
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.2 Start 154,387,504 bp[1] End 154,510,659 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 7,119,063 bp[2] End 7,212,237 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • membrane • cell membrane • apical plasma membrane Biological process • regulation of signal transduction • positive regulation of sodium ion transport • negative regulation of peptidyl-serine phosphorylation • negative regulation of ERK1 and ERK2 cascade • positive regulation of sodium ion transmembrane transporter activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	154043	215748
Ensembl	ENSG00000153721	ENSMUSG00000015202
UniProt	Q6P9H4	Q8BMA3
RefSeq (mRNA)	NM_173515	NM_172546
RefSeq (protein)	NP_775786 NP_001355045 NP_001355046 NP_001355047 NP_001355048	NP_766134
Location (UCSC)	Chr 6: 154.39 – 154.51 Mb	Chr 10: 7.12 – 7.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000153721 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015202 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CNKSR family member 3". Retrieved 2018-08-31.

Further reading

• Ziera T, Irlbacher H, Fromm A, Latouche C, Krug SM, Fromm M, Jaisser F, Borden SA (November 2009). "Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel". FASEB J. 23 (11): 3936–46. doi:10.1096/fj.09-134759. PMID 19567370. S2CID 7476404.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Attar MA, Salem JC, Pursel HS, Santy LC (February 2012). "CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration". Exp. Cell Res. 318 (3): 228–37. doi:10.1016/j.yexcr.2011.10.018. PMID 22085542.
• Shin S, Park JS, Kim YJ, Oh T, An S, Park CS (May 2012). "Differential gene expression profile in PBMCs from subjects with AERD and ATA: a gene marker for AERD". Mol. Genet. Genomics. 287 (5): 361–71. doi:10.1007/s00438-012-0685-9. PMID 22457146. S2CID 14306121.
• Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D (September 2012). "Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex". J. Biol. Chem. 287 (39): 33014–25. doi:10.1074/jbc.M112.389148. PMC 3463358. PMID 22851176.
• Lake SL, Damato BE, Kalirai H, Dodson AR, Taktak AF, Lloyd BH, Coupland SE (March 2013). "Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival". Am. J. Pathol. 182 (3): 678–87. doi:10.1016/j.ajpath.2012.11.036. PMID 23357503.