COG5

Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.[5][6][7]

COG5
Identifiers
Aliases	COG5, CDG2I, GOLTC1, GTC90, component of oligomeric golgi complex 5
External IDs	OMIM: 606821 MGI: 2145130 HomoloGene: 42221 GeneCards: COG5
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.3 Start 107,201,555 bp[1] End 107,564,514 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A2-A3 Start 31,654,869 bp[2] End 31,937,630 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • cytoplasm • Golgi transport complex • Golgi membrane • cytosol • Golgi apparatus • membrane • nucleoplasm • trans-Golgi network membrane Biological process • protein transport • ER to Golgi vesicle-mediated transport • intra-Golgi vesicle-mediated transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10466	238123
Ensembl	ENSG00000164597 ENSG00000284369	ENSMUSG00000035933
UniProt	Q9UP83	Q8C0L8
RefSeq (mRNA)	NM_001161520 NM_006348 NM_181733	NM_001163126
RefSeq (protein)	NP_001154992 NP_006339 NP_859422 NP_001366440 NP_001366441 NP_001366442 NP_001366443 NP_001366444 NP_001366445	NP_001156598
Location (UCSC)	Chr 7: 107.2 – 107.56 Mb	Chr 12: 31.65 – 31.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM][7]

Interactions

COG5 has been shown to interact with COG7[8] and COG4.[8]

References

1. ENSG00000284369 GRCh38: Ensembl release 89: ENSG00000164597, ENSG00000284369 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035933 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walter DM, Paul KS, Waters MG (Dec 1998). "Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport". J Biol Chem. 273 (45): 29565–76. doi:10.1074/jbc.273.45.29565. PMID 9792665.
6. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
7. "Entrez Gene: COG5 component of oligomeric golgi complex 5".
8. Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. United States. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.

Further reading

• Chen X, Bykhovskaya Y, Tidow N, et al. (2000). "The familial mediterranean fever protein interacts and colocalizes with a putative Golgi transporter". Proc. Soc. Exp. Biol. Med. 224 (1): 32–40. doi:10.1046/j.1525-1373.2000.22362.x. PMID 10782044.
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
• Oka T, Vasile E, Penman M, et al. (2005). "Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells". J. Biol. Chem. 280 (38): 32736–45. doi:10.1074/jbc.M505558200. PMID 16051600.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
• Human COG5 genome location and COG5 gene details page in the UCSC Genome Browser.