CORO2A

Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.[5]

CORO2A
Identifiers
Aliases	CORO2A, CLIPINB, IR10, WDR2, coronin 2A
External IDs	OMIM: 602159 MGI: 1345966 HomoloGene: 2546 GeneCards: CORO2A
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.33 Start 98,120,975 bp[1] End 98,192,637 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 46,536,937 bp[2] End 46,602,202 bp[2]
Gene ontology Molecular function • actin binding • actin filament binding • GO:0001948 protein binding Cellular component • actin cytoskeleton • transcriptional repressor complex • intracellular Biological process • actin cytoskeleton organization • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7464	107684
Ensembl	ENSG00000106789	ENSMUSG00000028337
UniProt	Q92828	Q8C0P5
RefSeq (mRNA)	NM_003389 NM_052820	NM_001164804 NM_178893
RefSeq (protein)	NP_003380 NP_438171	NP_001158276 NP_849224
Location (UCSC)	Chr 9: 98.12 – 98.19 Mb	Chr 4: 46.54 – 46.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].[5]

References

1. GRCh38: Ensembl release 89: ENSG00000106789 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028337 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Coronin, actin binding protein, 2A". Retrieved 2012-01-03.

External links

• Human CORO2A genome location and CORO2A gene details page in the UCSC Genome Browser.

Further reading

• Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
• Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
• Marshall TW, Aloor HL, Bear JE (September 2009). "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". Journal of Cell Science. 122 (Pt 17): 3061–9. doi:10.1242/jcs.051482. PMC 2729258. PMID 19654210.
• Jin Y, Birlea SA, Fain PR, Mailloux CM, Riccardi SL, Gowan K, Holland PJ, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA (July 2010). "Common variants in FOXP1 are associated with generalized vitiligo". Nature Genetics. 42 (7): 576–8. doi:10.1038/ng.602. PMC 2893242. PMID 20526340.
• Zaphiropoulos PG, Toftgård R (December 1996). "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". DNA and Cell Biology. 15 (12): 1049–56. doi:10.1089/dna.1996.15.1049. PMID 8985118.