COX17

Cytochrome c oxidase copper chaperone is a protein that in humans is encoded by the COX17 gene.[5][6]

COX17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L0Y, 2LGQ, 2RN9, 2RNB
Identifiers
Aliases	COX17, cytochrome c oxidase copper chaperone, cytochrome c oxidase copper chaperone COX17
External IDs	OMIM: 604813 MGI: 1333806 HomoloGene: 38089 GeneCards: COX17
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.33 Start 119,654,513 bp[1] End 119,677,454 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3-B4 Start 38,346,991 bp[2] End 38,352,763 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • copper ion binding • GO:0001948 protein binding • metal ion binding • cuprous ion binding • copper chaperone activity Cellular component • mitochondrion • mitochondrial intermembrane space • cytoplasm Biological process • heart development • brain development • generation of precursor metabolites and energy • copper ion transport • positive regulation of cell proliferation • mitochondrial respiratory chain complex IV assembly • positive regulation of cytochrome-c oxidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10063	12856
Ensembl	ENSG00000138495	ENSMUSG00000046516
UniProt	Q14061	P56394
RefSeq (mRNA)	NM_005694	NM_001017429
RefSeq (protein)	NP_005685 NP_001368931 NP_001368932	NP_001017429
Location (UCSC)	Chr 3: 119.65 – 119.68 Mb	Chr 16: 38.35 – 38.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138495 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046516 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Amaravadi R, Glerum DM, Tzagoloff A (Mar 1997). "Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment". Hum Genet. 99 (3): 329–33. doi:10.1007/s004390050367. PMID 9050918. S2CID 30340147.
6. "Entrez Gene: COX17 COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)".

Further reading

• Punter FA, Adams DL, Glerum DM (2000). "Characterization and localization of human COX17, a gene involved in mitochondrial copper transport". Hum. Genet. 107 (1): 69–74. doi:10.1007/s004390050013. PMID 10982038.
• Horvath R, Lochmüller H, Stucka R, et al. (2000). "Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency". Biochem. Biophys. Res. Commun. 276 (2): 530–3. doi:10.1006/bbrc.2000.3495. PMID 11027508.
• Kako K, Tsumori K, Ohmasa Y, et al. (2000). "The expression of Cox17p in rodent tissues and cells". Eur. J. Biochem. 267 (22): 6699–707. doi:10.1046/j.1432-1327.2000.01771.x. PMID 11054125.
• Heaton DN, George GN, Garrison G, Winge DR (2001). "The mitochondrial copper metallochaperone Cox17 exists as an oligomeric, polycopper complex". Biochemistry. 40 (3): 743–51. doi:10.1021/bi002315x. PMID 11170391.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki C, Daigo Y, Kikuchi T, et al. (2004). "Identification of COX17 as a therapeutic target for non-small cell lung cancer". Cancer Res. 63 (21): 7038–41. PMID 14612491.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kako K, Takehara A, Arai H, et al. (2005). "A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p". Biochem. Biophys. Res. Commun. 324 (4): 1379–85. doi:10.1016/j.bbrc.2004.09.211. PMID 15504366.
• Arnesano F, Balatri E, Banci L, et al. (2005). "Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding". Structure. 13 (5): 713–22. doi:10.1016/j.str.2005.02.015. PMID 15893662.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Cobine PA, Pierrel F, Leary SC, et al. (2006). "The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding" (PDF). J. Biol. Chem. 281 (18): 12270–6. doi:10.1074/jbc.M600496200. PMID 16520371. S2CID 12826240.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
• Voronova A, Kazantseva J, Tuuling M, et al. (2007). "Cox17, a copper chaperone for cytochrome c oxidase: expression, purification, and formation of mixed disulphide adducts with thiol reagents". Protein Expr. Purif. 53 (1): 138–44. doi:10.1016/j.pep.2006.11.014. PMID 17208454.
• Voronova A, Meyer-Klaucke W, Meyer T, et al. (2007). "Oxidative switches in functioning of mammalian copper chaperone Cox17". Biochem. J. 408 (1): 139–48. doi:10.1042/BJ20070804. PMC 2049083. PMID 17672825.

External links

• COX17 human gene location in the UCSC Genome Browser.
• COX17 human gene details in the UCSC Genome Browser.