COX6C

Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.[4][5]

COX6C
Identifiers
Aliases	COX6C, cytochrome c oxidase subunit 6C
External IDs	OMIM: 124090 HomoloGene: 136781 GeneCards: COX6C
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 99,873,200 bp[1] End 99,893,707 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytochrome-c oxidase activity Cellular component • integral component of membrane • mitochondrial inner membrane • membrane • mitochondrion Biological process • hydrogen ion transmembrane transport • generation of precursor metabolites and energy • electron transport chain • mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1345	102640946
Ensembl	ENSG00000164919	n/a
UniProt	P09669	n/a
RefSeq (mRNA)	NM_004374	n/a
RefSeq (protein)	NP_004365	n/a
Location (UCSC)	Chr 8: 99.87 – 99.89 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000164919 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID 10072584.
5. "Entrez Gene: COX6C cytochrome c oxidase subunit VIc".

External links

• Human COX6C genome location and COX6C gene details page in the UCSC Genome Browser.

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–44. doi:10.1016/S0079-6603(08)60830-2. ISBN 9780125400619. PMID 9752724.
• Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841. S2CID 2286919.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kish SJ, Mastrogiacomo F, Guttman M, et al. (1999). "Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?". J. Neurochem. 72 (2): 700–7. doi:10.1046/j.1471-4159.1999.0720700.x. PMID 9930743. S2CID 32587972.
• Wang FL, Wang Y, Wong WK, et al. (1996). "Two differentially expressed genes in normal human prostate tissue and in carcinoma". Cancer Res. 56 (16): 3634–7. PMID 8705997.
• Otsuka M, Mizuno Y, Yoshida M, et al. (1989). "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc". Nucleic Acids Res. 16 (22): 10916. doi:10.1093/nar/16.22.10916. PMC 338951. PMID 2849755.