CPA5

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.[5][6]

CPA5
Identifiers
Aliases	CPA5, carboxypeptidase A5
External IDs	OMIM: 609561 MGI: 1921899 HomoloGene: 62246 GeneCards: CPA5
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.2 Start 130,344,816 bp[1] End 130,368,730 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 30,611,010 bp[2] End 30,631,745 bp[2]
Gene ontology Molecular function • carboxypeptidase activity • zinc ion binding • peptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • metallocarboxypeptidase activity Cellular component • extracellular region • extracellular Biological process • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	93979	74649
Ensembl	ENSG00000158525	ENSMUSG00000029788
UniProt	Q8WXQ8	Q8R4H4
RefSeq (mRNA)	NM_001127441 NM_001127442 NM_080385 NM_001318223	NM_144537
RefSeq (protein)	NP_001120913 NP_001120914 NP_001305152 NP_525124	NP_653120
Location (UCSC)	Chr 7: 130.34 – 130.37 Mb	Chr 6: 30.61 – 30.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000158525 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029788 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi:10.1074/jbc.M112254200. PMID 11836249.
6. "Entrez Gene: CPA5 carboxypeptidase A5".

External links

• Human CPA5 genome location and CPA5 gene details page in the UCSC Genome Browser.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome". J. Med. Genet. 40 (4): 249–56. doi:10.1136/jmg.40.4.249. PMC 1735416. PMID 12676894.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry. 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID 11920156.
• "A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium". Hum. Mol. Genet. 7 (3): 571–8. 1998. doi:10.1093/hmg/7.3.571. PMID 9546821.