CSN3 (gene)

Kappa-casein is a protein that in humans is encoded by the CSN3 gene.[5][6][7]

CSN3
Identifiers
Aliases	CSN3, CSN10, CSNK, KCA, CNS10, casein kappa
External IDs	OMIM: 601695 MGI: 107461 HomoloGene: 3818 GeneCards: CSN3
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 70,242,588 bp[1] End 70,251,428 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E1|5 43.56 cM Start 87,925,579 bp[2] End 87,932,665 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • extracellular region • extracellular Biological process • protein stabilization • lactation • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1448	12994
Ensembl	ENSG00000171209	ENSMUSG00000001622
UniProt	P07498	P06796
RefSeq (mRNA)	NM_005212	NM_007786 NM_001356570 NM_001356571
RefSeq (protein)	NP_005203	NP_031812 NP_001343499 NP_001343500
Location (UCSC)	Chr 4: 70.24 – 70.25 Mb	Chr 5: 87.93 – 87.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CSN3 (gene) has been shown to interact with EIF3S6.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000171209 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001622 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Edlund A, Johansson T, Leidvik B, Hansson L (Nov 1996). "Structure of the human kappa-casein gene". Gene. 174 (1): 65–9. doi:10.1016/0378-1119(96)00351-4. PMID 8863730.
6. Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M (Mar 1997). "Genomic organization and chromosomal localization of the human casein gene family". Hum Genet. 99 (3): 368–73. doi:10.1007/s004390050374. PMID 9050925. S2CID 8299892.
7. "Entrez Gene: CSN3 casein kappa".
8. Hoareau Alves, Karine; Bochard Valérie; Réty Stéphane; Jalinot Pierre (Sep 2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. Netherlands. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. ISSN 0014-5793. PMID 12220626. S2CID 39308598.

External links

• Human CSN3 genome location and CSN3 gene details page in the UCSC Genome Browser.

Further reading

• Bergström S, Hansson L, Hernell O, et al. (1993). "Cloning and sequencing of human kappa-casein cDNA". DNA Seq. 3 (4): 245–6. doi:10.3109/10425179209034024. PMID 1296818.
• Brignon G, Chtourou A, Ribadeau-Dumas B (1985). "Preparation and amino acid sequence of human kappa-casein". FEBS Lett. 188 (1): 48–54. doi:10.1016/0014-5793(85)80872-3. PMID 4018271. S2CID 83551753.
• Fiat AM, Jollès J, Aubert JP, et al. (1981). "Localisation and importance of the sugar part of human casein". Eur. J. Biochem. 111 (2): 333–9. doi:10.1111/j.1432-1033.1980.tb04946.x. PMID 7460900.
• Plowman JE, Creamer LK, Liddell MJ, Cross JJ (1999). "Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy". J. Dairy Res. 66 (1): 53–63. doi:10.1017/S0022029998003318. PMID 10191473.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Benítez MJ, Cochet C, Jiménez JS (2002). "A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin". Mol. Cell. Biochem. 227 (1–2): 31–6. doi:10.1023/A:1013140220121. PMID 11827172. S2CID 19295218.
• Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi:10.3168/jds.S0022-0302(02)74200-8. PMID 12146463.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim YJ, Park S, Oh YK, et al. (2005). "Purification and characterization of human caseinomacropeptide produced by a recombinant Saccharomyces cerevisiae". Protein Expr. Purif. 41 (2): 441–6. doi:10.1016/j.pep.2005.02.021. PMID 15866733.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.