CSTL1

Cystatin-like 1 is a protein that in humans is encoded by the CSTL1 gene.[5]

CSTL1
Identifiers
Aliases	CSTL1, CTES1, RCET11, dJ322G13.4, cystatin like 1
External IDs	MGI: 2652834 HomoloGene: 16283 GeneCards: CSTL1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,439,685 bp[1] End 23,444,930 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 148,750,358 bp[2] End 148,755,433 bp[2]
Gene ontology Molecular function • peptidase inhibitor activity • protease binding • cysteine-type endopeptidase inhibitor activity Cellular component • extracellular region • extracellular Biological process • negative regulation of peptidase activity • negative regulation of cysteine-type endopeptidase activity • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	128817	228756
Ensembl	ENSG00000125823	ENSMUSG00000055177
UniProt	Q9H114	Q80Y72
RefSeq (mRNA)	NM_138283	NM_177655 NM_001362207
RefSeq (protein)	NP_612140	NP_808323 NP_001349136
Location (UCSC)	Chr 20: 23.44 – 23.44 Mb	Chr 2: 148.75 – 148.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at the telomeric end of the cystatin locus and encodes a type 2 cystatin-like protein. The specific function of this protein has not been determined.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000125823 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055177 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CSTL1 cystatin-like 1".

External links

• Human CSTL1 genome location and CSTL1 gene details page in the UCSC Genome Browser.

Further reading

• Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. doi:10.1002/pro.5560060102. PMC 2143511. PMID 9007972.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. doi:10.1089/dna.1994.13.97. PMID 8179826.
• Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. 24 (1): 172–5. doi:10.1006/geno.1994.1595. PMID 7896273.
• Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. doi:10.1177/10454411930040034401. PMID 7690606.
• Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID 3202964.