CTNNAL1

Alpha-catulin is a protein that in humans is encoded by the CTNNAL1 gene.[5][6]

CTNNAL1
Identifiers
Aliases	CTNNAL1, ACRP, CLLP, alpha-CATU, catenin alpha like 1
External IDs	OMIM: 604785 MGI: 1859649 HomoloGene: 2815 GeneCards: CTNNAL1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.3 Start 108,942,569 bp[1] End 109,013,522 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B3 Start 56,810,935 bp[2] End 56,865,188 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin filament binding • GO:0001948 protein binding • cadherin binding Cellular component • cytoplasm • cytosol • cell membrane • cytoskeleton • membrane Biological process • cell adhesion • Rho protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8727	54366
Ensembl	ENSG00000119326	ENSMUSG00000038816
UniProt	Q9UBT7	O88327
RefSeq (mRNA)	NM_001286974 NM_003798	NM_018761
RefSeq (protein)	NP_001273903 NP_003789	NP_061231
Location (UCSC)	Chr 9: 108.94 – 109.01 Mb	Chr 4: 56.81 – 56.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CTNNAL1 has been shown to interact with AKAP13.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000119326 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038816 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI (Jan 1999). "Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin". Genomics. 54 (1): 149–54. doi:10.1006/geno.1998.5458. PMID 9806841.
6. "Entrez Gene: CTNNAL1 catenin (cadherin-associated protein), alpha-like 1".
7. Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (Nov 2002). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917.

External links

• Human CTNNAL1 genome location and CTNNAL1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Janssens B, Staes K, van Roy F (1999). "Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing". Biochim. Biophys. Acta. 1447 (2–3): 341–7. doi:10.1016/s0167-4781(99)00170-0. PMID 10542337.
• Demacio PC, Ray PN (2002). "Alpha-catulin maps to the familial dysautonomia region on 9q31". Genome. 44 (6): 990–4. doi:10.1139/gen-44-6-990. PMID 11768226.
• Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (2003). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917.
• Shieh YS, Chang LC, Chiu KC, Wu CW, Lee HS (2003). "Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome". J. Oral Pathol. Med. 32 (5): 297–304. doi:10.1034/j.1600-0714.2003.00144.x. PMID 12694354.
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
• Merdek KD, Nguyen NT, Toksoz D (2004). "Distinct Activities of the α-Catenin Family, α-Catulin and α-Catenin, on β-Catenin-Mediated Signaling". Mol. Cell. Biol. 24 (6): 2410–22. doi:10.1128/mcb.24.6.2410-2422.2004. PMC 355851. PMID 14993280.