CWC15

Protein CWC15 homolog is a protein that in humans is encoded by the CWC15 gene.[5][6][7]

CWC15
Identifiers
Aliases	CWC15, AD002, C11orf5, Cwf15, HSPC148, ORF5, CWC15 spliceosome-associated protein, CWC15 spliceosome associated protein homolog
External IDs	MGI: 1913320 HomoloGene: 9499 GeneCards: CWC15
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q21 Start 94,962,620 bp[1] End 94,973,586 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A2 Start 14,500,617 bp[2] End 14,510,577 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding Cellular component • catalytic step 2 spliceosome • spliceosomal complex • cell nucleus • nucleoplasm • mitochondrion • nuclear speck • U2-type catalytic step 2 spliceosome Biological process • mRNA processing • RNA splicing • mRNA splicing, via spliceosome • mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51503	66070
Ensembl	ENSG00000150316	ENSMUSG00000004096
UniProt	Q9P013	Q9JHS9
RefSeq (mRNA)	NM_016403 NM_001363371 NM_001363372	NM_023153
RefSeq (protein)	NP_057487 NP_001350300 NP_001350301	NP_075642
Location (UCSC)	Chr 11: 94.96 – 94.97 Mb	Chr 9: 14.5 – 14.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CWC15 has been shown to interact with CDC5L.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000150316 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004096 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. O'Brien KP, Tapia-Paez I, Stahle-Backdahl M, Kedra D, Dumanski JP (Jul 2000). "Characterization of five novel human genes in the 11q13-q22 region". Biochem Biophys Res Commun. 273 (1): 90–4. doi:10.1006/bbrc.2000.2910. PMID 10873569.
6. Ohi MD, Link AJ, Ren L, Jennings JL, McDonald WH, Gould KL (Mar 2002). "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs". Mol Cell Biol. 22 (7): 2011–24. doi:10.1128/MCB.22.7.2011-2024.2002. PMC 133674. PMID 11884590.
7. "Entrez Gene: HSPC148 hypothetical protein HSPC148".
8. Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

External links

• Human CWC15 genome location and CWC15 gene details page in the UCSC Genome Browser.

Further reading

• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.