Carbidopa/levodopa

Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa.[1] It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse.[1] It is taken by mouth.[1] It can take two to three weeks of treatment before benefits are seen.[2] Each dose then begins working in about ten minutes to two hours with a duration of effect of about five hours.[2][3][4]

Carbidopa/levodopa
Combination of
AgonistLevodopa
Enzyme inhibitorCarbidopa
Clinical data
Trade namesAtamet, Carbilev, Sinemet, others
AHFS/Drugs.comMonograph
MedlinePlusa601068
License data
Pregnancy
category
  • AU: B3
ATC code
Legal status
Legal status
Identifiers
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
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Common side effects include movement problems and nausea.[1] More serious side effects include depression, low blood pressure with standing, sudden onset of sleepiness, psychosis, and increased risk-taking behavior.[1][5] Carbidopa prevents the breakdown of levodopa outside the brain.[5] In the brain, levodopa is broken down into dopamine, its active form.[5] Carbidopa also helps prevent some of the nausea which levodopa causes.[6]

It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[5] In 2017, it was the 184th most commonly prescribed medication in the United States, with more than three million prescriptions.[8][9]

Medical uses

Parkinson's disease

It is primarily used to improve the symptoms of Parkinson's disease but does not change the course of the disease.[1] It can take two to three weeks of treatment before benefits are seen.[2] Each dose then begins working in about ten minutes to two hours depending on the formulation, with a duration of effect of about five hours.[2][3][4]

A formulation that can be given in an intra-intestinal pump, known as Duodopa, is being developed.[10][11]

Other

Other uses include for dopamine-responsive dystonia (DRD) and restless legs syndrome.[5]

There is tentative evidence that it is useful in amblyopia when used with other treatments.[12]

Side effects

Common side effects include dizziness, drowsiness, blurred vision, vomiting, nausea, dry mouth, low appetite, heartburn, diarrhea, constipation, frequent sneezing, stuffiness of the nose, any of the symptoms of ordinary common cold, cough, muscle pain, hallucinations, numbness or a tingling sensation, disturbances of sleep, skin rash, itching, and/or headache.[13]

Less common, but more serious, side effects can include very frequent blinking or twitching of the eyes, fainting, mood changes such as confusion, depression, hallucinations, thoughts of suicide, or unusual strong urges (such as increased gambling, increases in the sex-drive, delusions (strongly-felt belief in something which is obviously not true) worsening of involuntary movements or spasms, and/or other movement problems. Patients should report these to their doctors as soon as possible.[13][1]

Mechanism of action

Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Activation of central dopamine receptors improves the symptoms of Parkinson's disease; however, activation of peripheral dopamine receptors causes nausea and vomiting. For this reason levodopa is usually administered in combination with a DOPA decarboxylase inhibitor (DDCI), in this case carbidopa, which is very polar (and charged at physiologic pH) and cannot cross the blood brain barrier, however prevents peripheral conversion of levodopa to dopamine and thereby reduces the unwanted peripheral side effects of levodopa. Use of carbidopa also increases the quantity of levodopa in the bloodstream that is available to enter the brain.

History

In 1960 the Austrian biochemist Oleh Hornykiewicz, while at the University of Vienna, examined results of autopsies of patients who had died with Parkinson's disease. He suggested that the disease was associated with, or caused by, a reduction in the levels of dopamine in the basal ganglia of the brain. Since dopamine itself did not enter the brain, he tried treating twenty patients with a racemic mixture of dihydroxyphenylalanine (DOPA), which could enter the brain and be converted there to dopamine by the action of DOPA decarboxylase. His results were positive, as were those of another trial in Montreal run by André Barbeau. Unfortunately, other investigators were unable to replicate these early results, and the use of DOPA remained in question until 1967, when George Cotzias at the Brookhaven National Laboratories in Upton, New York, used megadoses of DOPA, up to 16 grams per day. Not long after these results became known, Curt Porter at Merck showed that L-DOPA was the active stereoisomer, thus reducing the effective dose to half.[14]

With L-DOPA identified as the active form, Alfred Pletscher and his colleagues at Hoffman-LaRoche synthesized benserazide, an inhibitor of DOPA decarboxylase, which further reduced the required dose. A drug combining L-DOPA with benserazide was marketed under the brand name of Madopar. Independent work was carried out by Victor Lotti at Merck in West Point, Pennsylvania. Merck had already synthesized and patented carbidopa, another dopa decarboxylase inhibitor in 1962, and in 1971 Lotti showed that the use of the L-form of carbidopa, further reduced the therapeutic dose of L-DOPA. The combination of L-carbidopa and L-DOPA was marketed under the brand name of Sinemet.[14]

Society and culture

Cost

It is available as a generic medication and is moderately expensive.[5]

Names

The generic name under the BAN system is Co-careldopa.

It is sold under several brand names, including Sinemet (Merck Sharp & Dohme Limited), Pharmacopa, Atamet, Apo-Levocarb, Duodopa, Kinson, and Pharmacopa, among others.

Extended-release formulations are sold as Rytary and Sinemet-CR. An extended-release enteral solution is sold as Duopa.

Shortages

In 1991, Merck licensed the rights to the manufacture and sale of Sinemet to a newly created joint venture, DuPont Merck Pharmaceutical Company. That same year, approvals for a sustained release formulation (Sinemet CR) which could be taken less frequently were also obtained.[15] DuPont purchased Merck's share in the joint venture in 1998 and began operating the company as DuPont Pharmaceuticals (DuPont Pharma), but Merck continued to manufacture the drug for DuPont.[16] Starting in late 2009 and continuing into 2011 Merck stopped manufacturing the drug while awaiting regulatory approvals due to a change in the supplier of the active ingredient. This resulted in shortages of the brand name products Sinemet and Sinemet CR, although alternative generic versions were still available.[17]

Another shortage appears to have occurred at the end of 2017.[18][19]

See also

References
  1. "Levodopa/Carbidopa". The American Society of Health-System Pharmacists. Archived from the original on 24 September 2015. Retrieved 21 August 2015.
  2. Pharmacology and the Nursing Process. Elsevier Health Sciences. 2014. p. 246. ISBN 9780323293617. Archived from the original on 5 July 2017.
  3. Atlee, John L. (2007). Complications in anesthesia (2nd ed.). Philadelphia: Elsevier/Saunders. p. 490. ISBN 9781416022152. Archived from the original on 15 March 2017.
  4. The new Parkinson's disease treatment book : partnering with your doctor to get the most from your medications (2 ed.). Oxford University Press. 2015. p. 227. ISBN 9780190231866.
  5. Hamilton, Richard J. (2013). Tarascon pocket pharmacopoeia (14th ed.). Burlington, MA.: Jones & Bartlett Learning. p. 303. ISBN 9781449673635. Archived from the original on 12 January 2016.
  6. Ahlskog, J. Eric (2009). Parkinson's Disease Treatment Guide for Physicians. Oxford University Press. p. 124. ISBN 978-0-19-537177-2.
  7. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  9. "Carbidopa; Levodopa - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
  10. "Fact sheet - Duodopa (levodopa/carbidopa intestinal gel)". Hc-sc.gc.ca. 11 August 2010. Archived from the original on 11 January 2013. Retrieved 5 February 2013.
  11. "Abbott Healthcare - Information on Duodopa". Duodopa.co.uk. Archived from the original on 1 January 2013. Retrieved 5 February 2013.
  12. DeSantis, D (June 2014). "Amblyopia". Pediatric Clinics of North America. 61 (3): 505–18. doi:10.1016/j.pcl.2014.03.006. PMID 24852148.
  13. https://www.rxlist.com/sinemet-side-effects-drug-center.htm
  14. Scriabine, Alexander (1999). "Discovery and Development of Major Drugs Currently in Use", pp. 222–223 in Pharmaceutical Innovation: Revolutionizing Human Health, edited by Ralph Landau, Basil Achilladelis, and Alexander Scriabine. Philadelphia: Chemical Heritage Press. ISBN 978-0-941901-21-5.
  15. Sinemet Archived 11 May 2011 at the Wayback Machine at Dupont Heritage.
  16. SINEMET at listingdrugs.com Archived 3 May 2012 at the Wayback Machine
  17. Letter From MERCK About SINEMET Shortage Archived 3 July 2011 at the Wayback Machine at Bibmomma's Blog – Reflections of an early onset Parkinson's patient.
  18. "FDA Drug Shortages". www.accessdata.fda.gov.
  19. "ASHP - 500 Error". www.ashp.org.
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