Carboxypeptidase U
Carboxypeptidase U (EC 3.4.17.20, arginine carboxypeptidase, carboxypeptidase R, plasma carboxypeptidase B, thrombin-activatable fibrinolysis inhibitor) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Release of C-terminal Arg and Lys from a polypeptide
| Carboxypeptidase U | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.17.20 | ||||||||
| CAS number | 156621-18-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
See also
References
- Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D (November 1991). "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma". The Journal of Biological Chemistry. 266 (32): 21833–8. PMID 1939207.
- Shinohara T, Sakurada C, Suzuki T, Takeuchi O, Campbell W, Ikeda S, Okada N, Okada H (1994). "Pro-carboxypeptidase R cleaves bradykinin following activation". International Archives of Allergy and Immunology. 103 (4): 400–4. doi:10.1159/000236661. PMID 8130654.
- Wang W, Hendriks DF, Scharpé SS (June 1994). "Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen". The Journal of Biological Chemistry. 269 (22): 15937–44. PMID 8195249.
- Tan AK, Eaton DL (May 1995). "Activation and characterization of procarboxypeptidase B from human plasma". Biochemistry. 34 (17): 5811–6. doi:10.1021/bi00017a012. PMID 7727441.
- Broze GJ, Higuchi DA (November 1996). "Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma". Blood. 88 (10): 3815–23. PMID 8916945.
External links
- Carboxypeptidase+U at the US National Library of Medicine Medical Subject Headings (MeSH)
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