Carl Faingold

Carl L. Faingold, Ph.D. is a neuroscientist, a Distinguished Professor in the Department of Pharmacology of Southern Illinois University School of Medicine in Springfield, Illinois; he is a founding faculty member of both the department and the School of Medicine. He has had an extensive career as a medical and graduate student educator as well as a researcher into brain mechanisms. He is a specialist in the actions of drugs on brain activity at the level of the single neuron as it relates to networks of neurons in awake behaving animals.

Dr. Carl Faingold in his office at SIU School of Medicine

Education

Faingold received his B.S. in Pharmacy from the University of Illinois at Chicago in 1965, and a Ph.D. in pharmacology from Northwestern University in 1970. This was followed by a post-doctoral fellowship at the University of Missouri Institute of Psychiatry. He is a long-time member of the American Society for Pharmacology and Experimental Therapeutics ASPET,[1] the Research Society on Alcoholism RSA,[2] the American Epilepsy Society (AES),[3] and the Society for Neuroscience (SfN).[4]

Research Interests

A current major research direction in Dr. Faingold’s lab is in the area of sudden unexpected death in epilepsy (SUDEP), which is a devastating and relatively rare problem that can occur in patients with epilepsy.[5] Th Since first publishing about a mouse model of SUDEP in 2007 in DBA mice,[6] His lab has explored the role of brain chemicals, serotonin and adenosine, in potential preventative treatments for SUDEP in these mice,[6] including a possible role of agents that enhance the action of serotonin in SUDEP prevention. These agents include selective serotonin reuptake inhibitors (SSRIs) which prevent SUDEP in mice with some evidence of potential usefulness in human epileptic patients as well.[7]

His lab has published several recent papers on the subject of SUDEP prevention in two mouse models of SUDEP in DBA/1 and DBA/2 mice.[8][9]

Publications

He has participated in the writing of the "AMSPC Knowledge Objectives in Pharmacology" as co-editor with Richard Eisenberg, . of the 2012 update and expansion of these pharmacology teaching objectives.[10] He also served as co-editor of Brody’s Human Pharmacology] with Lynn Wecker, George Dunaway, Lynn Crespo and Stephanie Watts.

Faingold has recently (2014) published a book with co-editor, Hal Blumenfeld, Professor of Neurology, Neuroscience and Neurosurgery at Yale University School of Medicine.Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics[11]

Awards

Faingold was named Distinguished Scholar of the Southern Illinois University system in 2009.

Further reading
  • Uteshev, V.V., S. Tupal, Y. Mhaskar, and C. L. Faingold. Abnormal serotonin receptor expression in DBA/2 mice associated with susceptibility to sudden death due to respiratory arrest. Epilepsy Res. 88, pp. 183–188, 2010
  • Faingold, C.L., Tupal, S. and Randall, M. Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor. Epilepsy Behav., 22:186-190, 2011.
  • Faingold, C.L., Randall, M. Mhaskar, Y. and Uteshev, V. V.. Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice. Brain Res., 1418:104-110, 2011.
  • Faingold CL, Tupal S, Mhaskar Y, Uteshev VV. DBA mice as models of sudden unexpected death in epilepsy. IN: Sudden Death in Epilepsy: Forensic and Clinical Issue, (C. Lathers, P. Schraeder, M. Bungo, J. Leestma, editors), Taylor and Francis, 657-674, 2010.
  • Faingold CL. Brainstem networks: reticulo-cortical synchronization in generalized convulsive seizures. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds. Jasper's Basic Mechanisms of the Epilepsies. 4th ed. New York, NY: Oxford University Press, 2012: 257-271. Bethesda (MD): National Center for Biotechnology Information (US). Available from: http://preview.ncbi.nlm.nih.gov/books/NBK82044/.
  • Feng, H.J., Faingold, C.L. Ketamine in mood disorders and epilepsy. In: Costa A and Villalba E, eds. Horizons in Neuroscience Research, Vol. 10. P. 103-122, Nova Science Publishers, New York, 2013.

References
  1. "ASPET". www.aspet.org.
  2. "Home Page". www.rsoa.org.
  3. http://www.aesnet.org
  4. "Website Home Page". www.sfn.org.
  5. L. Nashef, E. L. So, P. Ryvlin, and T. Tomson. Unifying the definitions of sudden unexpected death in epilepsy. Epilepsia 53 (2):227-233, 2012.
  6. S. Tupal and C. L. Faingold. Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice. Epilepsia 47 (1):21-26, 2006.
  7. L. M. Bateman, C. S. Li, T. C. Lin, and M. Seyal. Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy. Epilepsia 51 (10):2211-2214, 2010.
  8. C. L. Faingold and M. Randall. Effects of age, sex, and sertraline administration on seizure-induced respiratory arrest in the DBA/1 mouse model of sudden unexpected death in epilepsy (SUDEP). Epilepsy Behav. 28 (1):78-82, 2013.
  9. C. L. Faingold, S. P. Kommajosyula, X. Long, K. Plath, and M. Randall. Serotonin and sudden death: Differential effects of serotonergic drugs on seizure-induced respiratory arrest in DBA/1 mice. Epilepsy Behav. 37C:198-203, 2014.
  10. "Archived copy". Archived from the original on 2014-11-17. Retrieved 2014-08-15.CS1 maint: archived copy as title (link)
  11. Faingold, Carl, and Hal Blumenfeld. Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics. London: Academic Press, 2014. ISBN 9780124158641
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