Carl Wu

Carl Wu is a Chinese-American scientist, and a Bloomberg Distinguished Professor of biology, molecular biology and genetics at Johns Hopkins University.[1] He is active in the fields of chromatin and gene expression.

Carl Wu
CitizenshipAmerican
Education
AwardsNational Academy of Medicine (2010)

National Academy of Sciences (2006)
American Academy of Arts and Sciences
European Molecular Biology Organization

Academia Sinica
Scientific career
FieldsMolecular Biology, Genetics, Biochemistry
InstitutionsJohns Hopkins University (Since 2016)
Howard Hughes Medical Institute (2012-2016)
National Cancer Institute (1982-2012)

Early life and education

Carl Wu was born in Hong Kong. Wu attended St. Joseph's High School in Hong Kong and won a scholarship to attend Saint Mary's College of California. He began his research in chromatin biology while pursuing his doctorate at Harvard University, under Sarah Elgin. Subsequently Wu completed his post-doc as a Junior fellow of the Harvard Society of Fellows under Nobel laureate Walter Gilbert, where he provided the first evidence for DNase hypersensitive sites at cellular gene promoters.[2]

Career

National Cancer Institute and HHMI

In 1982, Wu joined the National Cancer Institute within the National Institutes of Health. Here he began investigating the biochemical mechanism of chromatin remodeling. In 1994, his group discovered that enzymatic activity was necessary for creating accessible DNA sites on chromatin. The following year his lab purified and characterized the responsible chromatin remodeling enzyme called NURF. This work was recognized by Nature as a breakthrough discovery in the field of gene expression. Wu went on to become the chief of the Laboratory for Molecular Cell Biology at the cancer institute; then chief of the Laboratory of Biochemistry and Molecular Biology.[3]

In 2012, Wu joined Janelia Research Campus of the Howard Hughes Medical Institute as a Senior Fellow of the Transcription Imaging Consortium.

Johns Hopkins University

In 2016, Wu joined the Johns Hopkins University as the 23rd Bloomberg Distinguished Professor. His appointment bridges the Department of Biology in JHU's Zanvyl Krieger School of Arts and Sciences and the Department of Molecular Biology and Genetics in the School of Medicine. Through this interdisciplinary appointment, Wu combined his research efforts in biochemistry and live cell imaging into a single unified effort.[4]

Awards

Wu was elected as a member of the National Academy of Sciences in 2006 and the National Academy of Medicine in 2010.[5][6]

References
  1. "Carl Wu | Department of Biology". Department of Biology. Retrieved 2018-07-16.
  2. "The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I". Nature. 1980-08-28. Retrieved 2018-12-06.
  3. "Carl Wu, Ph.D." Center for Cancer Research. 2014-08-12. Retrieved 2018-07-16.
  4. "Renowned scientist Carl Wu named Bloomberg Distinguished Professor at Johns Hopkins". The Hub. 2016-08-03. Retrieved 2018-07-16.
  5. http://www.nasonline.org, National Academy of Sciences -. "Carl Wu". www.nasonline.org. Retrieved 2018-07-16.
  6. "Five NIH leaders elected to the Institute of Medicine". National Institutes of Health (NIH). 2015-09-01. Retrieved 2018-07-16.
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