Caspase-10

Caspase-10 (EC 3.4.22.63, FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1beta-converting enzyme 2) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly
Caspase-10
Identifiers
EC number3.4.22.63
CAS number189088-85-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62).

References
  1. Chang HY, Yang X (December 2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiology and Molecular Biology Reviews. 64 (4): 821–46. doi:10.1128/mmbr.64.4.821-846.2000. PMC 99015. PMID 11104820.
  2. Fischer U, Stroh C, Schulze-Osthoff K (January 2006). "Unique and overlapping substrate specificities of caspase-8 and caspase-10". Oncogene. 25 (1): 152–9. doi:10.1038/sj.onc.1209015. PMID 16186808.
  3. Shikama Y, Yamada M, Miyashita T (July 2003). "Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases". European Journal of Immunology. 33 (7): 1998–2006. doi:10.1002/eji.200324013. PMID 12884866.
  4. Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS (September 2004). "Activation of caspases-8 and -10 by FLIP(L)". The Biochemical Journal. 382 (Pt 2): 651–7. doi:10.1042/bj20040809. PMC 1133822. PMID 15209560.
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