Christie G. Enke

Christie G. Enke is a United States academic chemist who made pioneering contributions to the field of analytical chemistry.

Christie G. Enke
BornJuly 8, 1933 (1933-07-08) (age 87)
Minneapolis, MN
NationalityUnited States
Alma materPrincipia College
University of Illinois
Known forElectrospray ionization
Mass Spectrometry
chemical instrumentation
Scientific career
FieldsChemist
InstitutionsPrinceton University
Michigan State University
University of New Mexico
Doctoral advisorHerbert August Laitinen

Life and career

Chris Enke was born in Minneapolis, Minnesota on July 8, 1933. His parents were Alvin Enke and Mae Nichols. He graduated from Central High School in Minneapolis in 1951. He received a BA degree from Principia College in 1955 and a Ph.D. from the University of Illinois in 1959. His thesis, concerning the anodic formation of surface oxide films on platinum electrodes, was performed under the guidance of Herbert Laitinen. While at Illinois, he also worked with Howard Malmstadt to introduce a graduate lab and lecture course in the electronics of laboratory instrumentation. He is now Professor Emeriti of Chemistry at the University of New Mexico and Michigan State University. Prior to his move to the University of New Mexico in 1994, he was an instructor and assistant professor at Princeton (1959 –1966), then an associate professor and professor at Michigan State University.

External video
Chris Enke, on the Triple Quadrupole breakthrough discovery: "It's a really interesting story because ... one man's noise is another man's answer.", Chemical Heritage Foundation

Education

Research and Teaching
  • Electroanalytical chemistry: Enke’s early research in electrochemistry centered on high-speed charge transfer kinetic studies.[1] He also pioneered the use of operational amplifiers in electroanalytical instrumentation and later, computer control. He is co-inventor of the bipolar pulse method for measuring electrolytic conductance.[2]
  • Teaching electronics to scientists: Howard Malmstadt and Enke wrote the pioneering work, Electronics for Scientists.[3] Then Malmstadt, Stan Crouch, and Enke wrote eight more texts and lab books in the electronics of laboratory instrumentation. This same team developed and presented the hands-on ACS short course, Electronics for Laboratory Instrumentation beginning in 1979. Enke also wrote an introductory analytical chemistry text called The Art and Science of Chemical Analysis.[4]
  • Mass spectrometry: Enke, his graduate student, Rick Yost, and a colleague, James Morrison, discovered low-energy collisional ion fragmentation in 1979.[5] Collisional dissociation in an RF-only quadrupole mass filter between two quadrupole mass analyzers resulted in the first triple quadrupole mass spectrometer.[6] Its low cost and unit resolution ushered in the technique now known as tandem mass spectrometry. Enke continued research in mass spectrometry including developing a distributed microprocessor control system for the triple-quadrupole,[7][8] a fast integrating detector system for time-of-flight mass spectrometry,[9] development of a tandem time-of-flight instrument with photofragmentation of ions,[10] the equilibrium partition theory of electrospray ionization,[11] and the invention of distance-of-flight mass spectrometry.[12]
  • Comprehensive analysis of complex mixtures: With Luc Nagels, Enke discovered that the concentrations of components in many natural complex mixtures have a log-normal distribution.[13] With this information, one can learn the number and concentrations of components that are below the detection limit.

Awards
  • 1974 American Chemical Society Award for Chemical Instrumentation
  • 1981 Fellow, American Association for the Advancement of Science
  • 1989 American Chemical Society Award for Computers in Chemistry
  • 1992 Michigan State University Distinguished Faculty Award
  • 1993 Distinguished Contribution in Mass Spectrometry Award (shared with Richard Yost)[14]
  • 2003 J. Calvin Giddings Award for Excellence in Education from Analytical Division of the American Chemical Society
  • 2011 American Chemical Society Award in Analytical Chemistry
  • 2011 Fellow, American Chemical Society
  • 2014 Distinguished Service in the Advancement of Analytical Chemistry Award from the Analytical Division of the American Chemical Society
  • 2015 Eastern Analytical Symposium Award for Outstanding Achievements in the Fields of Analytical Chemistry

References
  1. Daum, Peter H.; Enke, Christie G. (1969). "Electrochemical kinetics of the ferri-ferrocyanide couple on platinum". Analytical Chemistry. 41 (4): 653–656. doi:10.1021/ac60273a007. ISSN 0003-2700.
  2. Johnson, Donald Edwin.; Enke, C. G. (1970). "Bipolar pulse technique for fast conductance measurements". Analytical Chemistry. 42 (3): 329–335. doi:10.1021/ac60285a015. ISSN 0003-2700.
  3. Malmstadt, Howard; Enke, Christie (1962). Electronics for Scientists. New York: W. A. Benjamin.
  4. 1933-, Enke, Christie G. (2001). The art and science of chemical analysis. Wiley. OCLC 681424927.CS1 maint: numeric names: authors list (link)
  5. Yost, R.A.; Enke, C.G.; McGilvery, D.C.; Smith, D.; Morrison, J.D. (June 1979). "High efficiency collision-induced dissociation in an RF-only quadrupole". International Journal of Mass Spectrometry and Ion Physics. 30 (2): 127–136. Bibcode:1979IJMSI..30..127Y. doi:10.1016/0020-7381(79)80090-x. ISSN 0020-7381.
  6. Yost, R. A.; Enke, C. G. (1978). "Selected ion fragmentation with a tandem quadrupole mass spectrometer". Journal of the American Chemical Society. 100 (7): 2274–2275. doi:10.1021/ja00475a072. ISSN 0002-7863.
  7. Newcome, B. H.; Enke, C. G. (1984). "Modular twin bus microprocessor system for laboratory automation". Review of Scientific Instruments. 55 (12): 2017–2022. Bibcode:1984RScI...55.2017N. doi:10.1063/1.1137705. ISSN 0034-6748.
  8. Enke, C. G. (1982-02-12). "Computers in Scientific Instrumentation". Science. 215 (4534): 785–791. doi:10.1126/science.215.4534.785. ISSN 0036-8075. PMID 17747841. S2CID 46561693.
  9. Stults, J. T.; Myerholtz, C. A.; Newcome, B. H.; Enke, C. G.; Holland, J. F. (1985). "Data acquisition and instrument control system for ion flight time measurements in mass spectrometry". Review of Scientific Instruments. 56 (12): 2267–2273. Bibcode:1985RScI...56.2267S. doi:10.1063/1.1138362. ISSN 0034-6748.
  10. Seeterlin, M. A.; Vlasak, P. R.; Beussman, D. J.; McLane, R. D.; Enke, C. G. (1993). "High Efficiency Photo-Induced Dissociation of Precursor Ions in a Tandem Time-of-Flight Mass Spectrometer". Journal of the American Society for Mass Spectrometry. 4 (9): 751–754. doi:10.1016/1044-0305(93)80055-4. ISSN 1044-0305. PMID 24226002.
  11. Enke, Christie G. (1997). "A Predictive Model for Matrix and Analyte Effects in Electrospray Ionization of Singly-Charged Ionic Analytes". Analytical Chemistry. 69 (23): 4885–4893. doi:10.1021/ac970095w. ISSN 0003-2700. PMID 9406535.
  12. Enke, Christie G.; Dobson, Gareth S. (2007). "Achievement of Energy Focus for Distance-of-Flight Mass Spectrometry with Constant Momentum Acceleration and an Ion Mirror". Analytical Chemistry. 79 (22): 8650–8661. doi:10.1021/ac070638u. ISSN 0003-2700. PMID 17929898.
  13. Enke, Christie G.; Nagels, Luc J. (2011). "Undetected Components in Natural Mixtures: How Many? What Concentrations? Do They Account for Chemical Noise? What Is Needed to Detect Them?". Analytical Chemistry. 83 (7): 2539–2546. doi:10.1021/ac102818a. ISSN 0003-2700. PMID 21366323.
  14. "Distinguished Contribution Past Recipients". American Society for Mass Spectrometry. Retrieved January 6, 2011.
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