DBC1

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[5][6][7][8][9]

BRINP1
Identifiers
Aliases	BRINP1, DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDs	OMIM: 602865 MGI: 1928478 HomoloGene: 8754 GeneCards: BRINP1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.1 Start 119,153,458 bp[1] End 119,369,435 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C1 Start 68,761,514 bp[2] End 68,954,397 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • neuronal cell body • dendrite • endoplasmic reticulum Biological process • cell cycle • negative regulation of cell cycle • cell death • cell cycle arrest • behavioral fear response • positive regulation of neuron differentiation • negative regulation of neurogenesis • social organism behavior • cellular response to retinoic acid • negative regulation of mitotic cell cycle • short-term memory • exploration behavior • maternal behavior • vocalization behavior Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1620	56710
Ensembl	ENSG00000078725	ENSMUSG00000028351
UniProt	O60477	Q920P3
RefSeq (mRNA)	NM_014618	NM_019967
RefSeq (protein)	NP_055433	NP_064351
Location (UCSC)	Chr 9: 119.15 – 119.37 Mb	Chr 4: 68.76 – 68.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[7]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

1. GRCh38: Ensembl release 89: ENSG00000078725 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028351 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
6. Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
7. "Entrez Gene: DBC1 deleted in bladder cancer 1".
8. Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
9. Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Further reading

• Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
• Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33". Genomics. 48 (3): 277–88. doi:10.1006/geno.1997.5165. PMID 9545632.
• Nishiyama H, Takahashi T, Kakehi Y, et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer". Genes Chromosomes Cancer. 26 (2): 171–5. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456.
• Nishiyama H, Gill JH, Pitt E, et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1". Oncogene. 20 (23): 2956–64. doi:10.1038/sj.onc.1204432. PMID 11420708. S2CID 3374427.
• Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors". J. Urol. 168 (6): 2645–9. doi:10.1016/s0022-5347(05)64236-x. PMID 12442002.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82–90. doi:10.1038/sj.onc.1206642. PMID 14712213. S2CID 3620390.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beetz C, Brodoehl S, Patt S, et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma". Oncol. Rep. 13 (2): 335–40. doi:10.3892/or.13.2.335 (inactive 2021-01-14). PMID 15643521.CS1 maint: DOI inactive as of January 2021 (link)
• Izumi H, Inoue J, Yokoi S, et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers". Hum. Mol. Genet. 14 (8): 997–1007. doi:10.1093/hmg/ddi092. PMID 15746151.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Louhelainen JP, Hurst CD, Pitt E, et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway". Oncogene. 25 (16): 2409–19. doi:10.1038/sj.onc.1209228. PMID 16369496. S2CID 3349365.