DCBLD2

Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the DCBLD2 gene.[5][6]

DCBLD2
Identifiers
Aliases	DCBLD2, CLCP1, ESDN, discoidin, CUB and LCCL domain containing 2
External IDs	OMIM: 608698 MGI: 1920629 HomoloGene: 12499 GeneCards: DCBLD2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q12.1|3 Start 98,795,941 bp[1] End 98,901,695 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.2 Start 58,408,443 bp[2] End 58,469,727 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • cell surface • integral component of plasma membrane • membrane Biological process • intracellular receptor signaling pathway • wound healing • negative regulation of cell growth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	131566	73379
Ensembl	ENSG00000057019	ENSMUSG00000035107
UniProt	Q96PD2	Q91ZV3
RefSeq (mRNA)	NM_080927	NM_028523 NM_001356484
RefSeq (protein)	NP_563615	NP_082799 NP_001343413
Location (UCSC)	Chr 3: 98.8 – 98.9 Mb	Chr 16: 58.41 – 58.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Model organisms

Model organisms have been used in the study of DCBLD2 function. A conditional knockout mouse line called Dcbld2^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]

Dcbld2 knockout mouse phenotype

Characteristic	Phenotype
All data available at.[8][13]
Peripheral blood leukocytes 6 Weeks	Abnormal
Haematology 6 Weeks	Normal
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Bone Marrow Immunophenotyping	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal

References

1. GRCh38: Ensembl release 89: ENSG00000057019 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035107 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kobuke K, Furukawa Y, Sugai M, Tanigaki K, Ohashi N, Matsumori A, Sasayama S, Honjo T, Tashiro K (Sep 2001). "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury". The Journal of Biological Chemistry. 276 (36): 34105–14. doi:10.1074/jbc.M105293200. PMID 11447234.
6. "Entrez Gene: DCBLD2 discoidin, CUB and LCCL domain containing 2".
7. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
8. "International Mouse Phenotyping Consortium".
9. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
10. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
11. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
12. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
13. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

• Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER (Sep 2007). "ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis". American Journal of Transplantation. 7 (9): 2098–105. doi:10.1111/j.1600-6143.2007.01919.x. PMID 17697260. S2CID 28463596.
• Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516. S2CID 23944956.
• Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (Sep 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Molecular & Cellular Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Koshikawa K, Osada H, Kozaki K, Konishi H, Masuda A, Tatematsu Y, Mitsudomi T, Nakao A, Takahashi T (Apr 2002). "Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo". Oncogene. 21 (18): 2822–8. doi:10.1038/sj.onc.1205405. PMID 11973641.
• Nadadur SS, Ehrke MJ, Gurtoo HL (Dec 1999). "A novel TNF-inducible message with putative growth suppressor function". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1489 (2–3): 433–9. doi:10.1016/s0167-4781(99)00189-x. PMID 10673047.